The Efficacy and Safety of CollaSel Pro Hydrolyzed Collagen Peptide Supplementation without Addons in Improving Skin Health in Adult Females: A Double Blind, Randomized, Placebo-Controlled Clinical Study Using Biophysical and Skin Imaging Techniques.

: This study aimed to evaluate the efficacy and safety of oral hydrolyzed collagen peptide (HCP) in healthy females by assessing the skin parameters via biophysical and skin imaging techniques. : 112 females were randomly assigned to receive either HCP ( = 57; 10 g CollaSel Pro) or placebo ( = 55; 10 g maltodextrin) daily for eight weeks. The contribution of HCP to skin elasticity, hydration, and roughness was investigated against a placebo, while the facial soft tissue sagging (RMS) and safety data were also recorded. : HCP was associated with significant improvements in skin elasticity ( = 0.009), skin hydration ( ranged from 0.003 to <0.001), and skin roughness ( ranged from 0.002 to <0.001). In the HCP vs. the placebo group, week eight values for skin elasticity (43.0 (7.4) vs. 40.3 (3.3) mPa, = 0.017), skin hydration (65.8 (18.9) vs. 53.1 (14.9) g/m, < 0.001) and skin roughness (40.2 (20.4) vs. 24.9 (20.9) g/m, < 0.001) were significantly higher. In the HCP group, week 8 RMS values were significantly lower than baseline values (1.02 (0.21) vs. 1.10 (0.21) mm, = 0.012). : CollaSel Pro HCP can be considered a well-tolerated, safe product that effectively improves dermal health and the appearance of sagging and ameliorates the signs of the aging process.