Dewar J A, Kerr G R
Br Med J (Clin Res Ed). 1985 Nov 23;291(6507):1464-7. doi: 10.1136/bmj.291.6507.1464.
The value of routine follow up of women treated for early breast cancer by mastectomy with or without postoperative radiotherapy was assessed retrospectively. Over eight years 546 patients made 6863 clinic visits, during which 192 first relapses were detected. Ninety three relapses were detected at scheduled (routine) visits and 99 at unscheduled (interval) visits. First relapses within the treated area or in the contralateral breast were detected significantly more commonly at routine visits than were first metastatic relapses (66/89 (74%) compared with 27/103 (26%)). Patients whose local relapse was detected at a routine visit had a significantly better survival than those whose local relapse was detected at an interval visit. A relapse that was potentially curable (local or in the contralateral breast) was detected at 66 (1%) of 6764 routine visits, but only 26 (39%) of these patients remained free of disease. It is concluded that the intensity of follow up of such patients could be reduced without any adverse effect on prognosis but with appreciable financial and other benefits.
对接受乳房切除术(无论是否术后放疗)治疗的早期乳腺癌女性进行常规随访的价值进行了回顾性评估。在八年期间,546名患者进行了6863次门诊就诊,在此期间检测到192例首次复发。93例复发在预定(常规)就诊时被检测到,99例在非预定(间隔)就诊时被检测到。在常规就诊时,治疗区域内或对侧乳房的首次复发比首次远处转移复发更常见(66/89(74%)对比27/103(26%))。在常规就诊时检测到局部复发的患者比在间隔就诊时检测到局部复发的患者生存情况显著更好。在6764次常规就诊中有66次(1%)检测到可能治愈的复发(局部或对侧乳房),但这些患者中只有26例(39%)仍无疾病。结论是,此类患者的随访强度可以降低,而不会对预后产生任何不利影响,同时会带来可观的经济和其他益处。