Russano Francesco, Brugnolo Davide, Bisetto Giovanni, Del Fiore Paolo, Rastrelli Marco, Mocellin Simone, Dall'Olmo Luigi
Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology (IOV), 35128 Padua, Italy.
Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy.
J Pers Med. 2024 Sep 16;14(9):984. doi: 10.3390/jpm14090984.
Basal cell carcinomas (BCCs) are common human malignancies with a rising incidence in recent years. While BCCs have a low mortality rate, they are often associated with significant local skin damage characterized by erythema, skin ulceration, and persistent pigmentation. Surgery, radiotherapy, and systemic chemotherapy have traditionally been the principal treatments for these skin injuries. However, electrochemotherapy has recently been proposed as a novel local treatment with promising results for various skin cancers, including BCC, while avoiding the side effects of conventional therapies. ECT involves a local electrical stimulus that enhances cell membrane permeability, thereby enabling the targeted intracellular accumulation of the chemotherapeutic agent.
We report a case of a 68-year-old man with an ulcerated BCC, following his progress up to 14 months post-ECT treatment, with positive outcomes.
We achieved a complete clinical response and noted an improvement in the patient's quality of life. This technique is fast, repeatable, requires minimal hospitalization, and reduces healthcare costs and adverse effects compared to major surgery. Therefore, it can be considered an alternative or complementary approach to traditional surgery for treating BCC of the head and neck.
基底细胞癌（BCC）是常见的人类恶性肿瘤，近年来发病率呈上升趋势。虽然基底细胞癌的死亡率较低，但它们通常会导致明显的局部皮肤损伤，表现为红斑、皮肤溃疡和持续性色素沉着。传统上，手术、放疗和全身化疗一直是这些皮肤损伤的主要治疗方法。然而，最近有人提出电化学疗法作为一种新型局部治疗方法，对包括基底细胞癌在内的各种皮肤癌都有 promising results ，同时避免了传统疗法的副作用。电化学疗法涉及局部电刺激，可增强细胞膜通透性，从而使化疗药物在细胞内靶向积累。
我们报告了一例68岁患有溃疡性基底细胞癌的男性患者，记录了其在接受电化学疗法治疗后长达14个月的病情进展，结果良好。
我们实现了完全的临床缓解，并注意到患者生活质量有所改善。与大型手术相比，该技术速度快、可重复、住院时间短，且降低了医疗成本和不良反应。因此，它可被视为治疗头颈部基底细胞癌的传统手术的替代或补充方法。
