Wang Xinyue, Liu Yang, Chen Zhiyuan, Wang Kexin, Liu Guangxiu, Chen Tuo, Zhang Binglin
Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.
Key Laboratory of Extreme Environmental Microbial Resources and Engineering, Lanzhou 730000, China.
Microorganisms. 2024 Aug 23;12(9):1748. doi: 10.3390/microorganisms12091748.
Radiation protection is an important field of study, as it relates to human health and environmental safety. Radiation-resistance mechanisms in extremophiles are a research hotspot, as this knowledge has great application value in bioremediation and development of anti-radiation drugs. Mount Everest, an extreme environment of high radiation exposure, harbors many bacterial strains resistant to radiation. However, owing to the difficulties in studying them because of the extreme terrain, many remain unexplored. In this study, a novel species (herein, S7-12) was isolated from the moraine of Mount Everest, and its morphology and functional and genomic characteristics were analyzed. The strain S7-12 is white in color, smooth and rounded, non-spore-forming, and non-motile and can survive at a UV intensity of 1000 J/m, showing that it is twice as resistant to radiation as . Radiation-resistance genes, including and those from the and gene families, were identified. The polyphasic taxonomic approach revealed that the strain S7-12 (=KCTC 59114T =GDMCC 1.3458T) is a new species of the genus and is thus proposed to be named . The in-depth study of the genome of strain S7-12 will enable us to gain further insights into its potential use in radiation resistance. Understanding how microorganisms resist radiation damage could reveal potential biomarkers and therapeutic targets, leading to the discovery of potent anti-radiation compounds, thereby improving human resistance to the threat of radiation.
辐射防护是一个重要的研究领域,因为它关系到人类健康和环境安全。极端微生物中的抗辐射机制是一个研究热点,因为这些知识在生物修复和抗辐射药物开发中具有很大的应用价值。珠穆朗玛峰是一个辐射暴露极高的极端环境,蕴藏着许多抗辐射细菌菌株。然而,由于极端地形给研究带来困难,许多菌株仍未被探索。在本研究中,从珠穆朗玛峰的冰碛中分离出一个新物种(在此称为S7-12),并对其形态、功能和基因组特征进行了分析。菌株S7-12呈白色,表面光滑且圆润,不形成芽孢,无运动能力,能在紫外线强度为1000 J/m²的环境下存活,表明其抗辐射能力是[此处原文缺失比较对象]的两倍。鉴定出了包括[此处原文缺失具体基因]以及来自[此处原文缺失具体基因家族]基因家族的抗辐射基因。多相分类方法表明,菌株S7-12(=KCTC 59114T =GDMCC 1.3458T)是[此处原文缺失属名]属的一个新物种,因此提议将其命名为[此处原文缺失新物种名]。对菌株S7-12基因组的深入研究将使我们能够进一步了解其在抗辐射方面的潜在用途。了解微生物如何抵抗辐射损伤可能会揭示潜在的生物标志物和治疗靶点,从而发现有效的抗辐射化合物,进而提高人类对辐射威胁的抵抗力。