Rajkhowa Sanchaita, Hussain Safrina Zeenat, Agarwal Manisha, Zaheen Alaiha, Al-Hussain Sami A, Zaki Magdi E A
Centre for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh 786004, Assam, India.
Department of Chemistry, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
Pharmaceutics. 2024 Sep 3;16(9):1160. doi: 10.3390/pharmaceutics16091160.
The increase in antibiotic-resistant bacteria presents a significant risk to worldwide public health, emphasizing the necessity of novel approaches to address infections. Quorum sensing, an essential method of communication among bacteria, controls activities like the formation of biofilms, the production of virulence factors, and the synthesis of secondary metabolites according to the number of individuals in the population. Quorum quenching, which interferes with these processes, emerges as a vital approach to diminish bacterial virulence and prevent biofilm formation. Nanocarriers, characterized by their small size, high surface-area-to-volume ratio, and modifiable surface chemistry, offer a versatile platform for the disruption of bacterial communication by targeting various stages within the quorum sensing pathway. These features allow nanocarriers to infiltrate biofilms, disrupt cell membranes, and inhibit bacterial proliferation, presenting a promising alternative to traditional antibiotics. Integrating nanocarrier-based systems into combination therapies provides a multi-pronged approach to infection control, enhancing both the efficacy and specificity of treatment regimens. Nonetheless, challenges related to the stability, safety, and clinical effectiveness of nanomaterial-based antimicrobial treatments remain. Continued research and development are essential to overcoming these obstacles and fully harnessing the potential of nano-antimicrobial therapies. This review emphasizes the importance of quorum sensing in bacterial behavior and highlights the transformative potential of nanotechnology in advancing antimicrobial treatments, offering innovative solutions to combat antibiotic-resistant pathogens.
抗生素耐药菌的增加对全球公共卫生构成了重大风险，凸显了采用新方法应对感染的必要性。群体感应是细菌之间一种重要的通讯方式，它根据群体中个体数量来控制生物膜形成、毒力因子产生以及次级代谢产物合成等活动。干扰这些过程的群体猝灭成为降低细菌毒力和防止生物膜形成的关键方法。纳米载体具有尺寸小、表面积与体积比高以及表面化学性质可修饰等特点，为通过靶向群体感应途径中的各个阶段来破坏细菌通讯提供了一个多功能平台。这些特性使纳米载体能够渗透生物膜、破坏细胞膜并抑制细菌增殖，是传统抗生素的一种有前景的替代方案。将基于纳米载体的系统整合到联合治疗中为感染控制提供了一种多管齐下的方法，可提高治疗方案的疗效和特异性。尽管如此，基于纳米材料的抗菌治疗在稳定性、安全性和临床有效性方面仍存在挑战。持续的研发对于克服这些障碍并充分发挥纳米抗菌疗法的潜力至关重要。本综述强调了群体感应在细菌行为中的重要性，并突出了纳米技术在推进抗菌治疗方面的变革潜力，为对抗抗生素耐药病原体提供了创新解决方案。
