Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu 525-8577, Japan.
Nutrients. 2024 Sep 13;16(18):3080. doi: 10.3390/nu16183080.
This study aimed to assess the effect of a combination of aerobic exercise training (ET) and (CH) intake on arterial nitric oxide (NO) production and arterial stiffness in obese rats. Twenty-week-old obese male rats were randomly grouped into four ( = 6): OBESE-SED (sedentary control), OBESE-ET (treadmill 25 m/min, 1 h, 5 d/week), OBESE-CH (0.5% powder in normal diet), and OBESE-ET+CH (combination of ET and CH intake) groups. The carotid-femoral pulse wave velocity (cfPWV), an index of arterial stiffness, was significantly lesser in the OBESE-ET, OBESE-CH, and OBESE-ET+CH groups than in the OBESE-SED group, and in the OBESE-ET+CH group significantly further enhanced these effects compared with the OBESE-ET and OBESE-CH groups. Additionally, arterial nitrate/nitrite (NOx) levels were significantly greater in the OBESE-ET, OBESE-CH, and OBESE-ET+CH groups than in the OBESE-SED group, and the OBESE-ET+CH group compared with the OBESE-ET and OBESE-CH groups. Furthermore, arterial NOx levels were positively correlated with arterial endothelial NO synthase phosphorylation levels (r = 0.489, 0.05) and negatively correlated with cfPWV (r = -0.568, 0.05). In conclusion, a combination of ET and CH intake may reduce arterial stiffness via an enhancement of the arterial NO signaling pathway in obese rats.
本研究旨在评估有氧运动训练(ET)和(CH)摄入相结合对肥胖大鼠动脉一氧化氮(NO)产生和动脉僵硬的影响。20 周龄肥胖雄性大鼠随机分为四组(n = 6):肥胖-安静(安静对照)、肥胖-ET(跑步机 25 m/min,1 h,每周 5 天)、肥胖-CH(正常饮食中 0.5%粉末)和肥胖-ET+CH(ET 和 CH 摄入的组合)组。颈动脉-股动脉脉搏波速度(cfPWV),动脉僵硬的指标,在肥胖-ET、肥胖-CH 和肥胖-ET+CH 组明显低于肥胖-安静组,并且在肥胖-ET+CH 组中与肥胖-ET 和肥胖-CH 组相比,这些效果进一步增强。此外,动脉硝酸盐/亚硝酸盐(NOx)水平在肥胖-ET、肥胖-CH 和肥胖-ET+CH 组明显高于肥胖-安静组,并且肥胖-ET+CH 组与肥胖-ET 和肥胖-CH 组相比。此外,动脉 NOx 水平与动脉内皮型一氧化氮合酶磷酸化水平呈正相关(r = 0.489,p = 0.05),与 cfPWV 呈负相关(r = -0.568,p = 0.05)。综上所述,ET 和 CH 摄入的组合可能通过增强肥胖大鼠的动脉 NO 信号通路来降低动脉僵硬。