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有氧运动训练与摄入减少肥胖大鼠动脉僵硬度通过增强动脉一氧化氮的产生。

Combined Aerobic Exercise Training and Intake Reduces Arterial Stiffness through Enhanced Arterial Nitric Oxide Production in Obese Rats.

机构信息

Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu 525-8577, Japan.

出版信息

Nutrients. 2024 Sep 13;16(18):3080. doi: 10.3390/nu16183080.

Abstract

This study aimed to assess the effect of a combination of aerobic exercise training (ET) and (CH) intake on arterial nitric oxide (NO) production and arterial stiffness in obese rats. Twenty-week-old obese male rats were randomly grouped into four ( = 6): OBESE-SED (sedentary control), OBESE-ET (treadmill 25 m/min, 1 h, 5 d/week), OBESE-CH (0.5% powder in normal diet), and OBESE-ET+CH (combination of ET and CH intake) groups. The carotid-femoral pulse wave velocity (cfPWV), an index of arterial stiffness, was significantly lesser in the OBESE-ET, OBESE-CH, and OBESE-ET+CH groups than in the OBESE-SED group, and in the OBESE-ET+CH group significantly further enhanced these effects compared with the OBESE-ET and OBESE-CH groups. Additionally, arterial nitrate/nitrite (NOx) levels were significantly greater in the OBESE-ET, OBESE-CH, and OBESE-ET+CH groups than in the OBESE-SED group, and the OBESE-ET+CH group compared with the OBESE-ET and OBESE-CH groups. Furthermore, arterial NOx levels were positively correlated with arterial endothelial NO synthase phosphorylation levels (r = 0.489, 0.05) and negatively correlated with cfPWV (r = -0.568, 0.05). In conclusion, a combination of ET and CH intake may reduce arterial stiffness via an enhancement of the arterial NO signaling pathway in obese rats.

摘要

本研究旨在评估有氧运动训练(ET)和(CH)摄入相结合对肥胖大鼠动脉一氧化氮(NO)产生和动脉僵硬的影响。20 周龄肥胖雄性大鼠随机分为四组(n = 6):肥胖-安静(安静对照)、肥胖-ET(跑步机 25 m/min,1 h,每周 5 天)、肥胖-CH(正常饮食中 0.5%粉末)和肥胖-ET+CH(ET 和 CH 摄入的组合)组。颈动脉-股动脉脉搏波速度(cfPWV),动脉僵硬的指标,在肥胖-ET、肥胖-CH 和肥胖-ET+CH 组明显低于肥胖-安静组,并且在肥胖-ET+CH 组中与肥胖-ET 和肥胖-CH 组相比,这些效果进一步增强。此外,动脉硝酸盐/亚硝酸盐(NOx)水平在肥胖-ET、肥胖-CH 和肥胖-ET+CH 组明显高于肥胖-安静组,并且肥胖-ET+CH 组与肥胖-ET 和肥胖-CH 组相比。此外,动脉 NOx 水平与动脉内皮型一氧化氮合酶磷酸化水平呈正相关(r = 0.489,p = 0.05),与 cfPWV 呈负相关(r = -0.568,p = 0.05)。综上所述,ET 和 CH 摄入的组合可能通过增强肥胖大鼠的动脉 NO 信号通路来降低动脉僵硬。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/913f/11434655/c01c59351f0c/nutrients-16-03080-g001.jpg

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