School of Pharmacy, Cedarville University, Cedarville, OH 45314, USA.
Nutrients. 2024 Sep 18;16(18):3148. doi: 10.3390/nu16183148.
S-adenosylmethionine (SAMe) is a natural compound used to improve mood-related symptoms. Our aim was to determine the efficacy, safety, and optimal dose of SAMe in Central Nervous System (CNS) signs (e.g., mood, behavior). We conducted a PRISMA-based systematic review by searching PubMed, CINAHL, and Web of Science using MeSH search terms. Articles were independently reviewed by two researchers (with a third resolving conflicts) during title/abstract screening and full-text review. Data were extracted in the same approach, with a quality assessment of included articles. Out of 1881 non-duplicated studies, 36 were included in the review focusing on CNS signs (mood, behavior, sleep). Most studies (n = 32) achieved a 4 or 5 out of 5 points, indicating high study quality. Overall, SAMe was effective in 24 of 36 studies, with adverse events mostly consisting of mild, transient gastrointestinal disturbances. Many patients in these studies did experience improvements in CNS signs from using SAMe alone or in combination with existing therapy. However, future studies are needed to further understand the long-term effects of SAMe in the CNS.
S-腺苷甲硫氨酸（SAMe）是一种天然化合物，用于改善与情绪相关的症状。我们的目的是确定 SAMe 在中枢神经系统（CNS）症状（如情绪、行为）方面的疗效、安全性和最佳剂量。我们使用 MeSH 搜索词在 PubMed、CINAHL 和 Web of Science 上进行了基于 PRISMA 的系统评价。在标题/摘要筛选和全文审查期间，由两名研究人员（由第三名解决冲突）独立审查文章。采用相同的方法提取数据，并对纳入的文章进行质量评估。在 1881 篇非重复研究中，有 36 篇研究集中于 CNS 症状（情绪、行为、睡眠）。大多数研究（n = 32）得分为 4 或 5 分（满分 5 分），表明研究质量较高。总体而言，SAMe 在 36 项研究中的 24 项研究中有效，不良反应主要为轻度、短暂的胃肠道紊乱。这些研究中的许多患者在单独使用 SAMe 或与现有疗法联合使用时确实改善了 CNS 症状。然而，需要进一步的研究来更深入地了解 SAMe 在 CNS 中的长期影响。
