Department of Dermato-Venereology, Zealand University Hospital, Roskilde, Denmark.
Department of Dermatology, Zealand University Hospital is a part of the European Reference Network On Rare and Undiagnosed Skin Disorders, Sygehusvej 10, 4000, Roskilde, Denmark.
Arch Dermatol Res. 2024 Sep 28;316(9):649. doi: 10.1007/s00403-024-03390-6.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with severe consequences on quality of life. One aspect of this is that HS has been linked to an increased risk of infertility, but as data is still limited, it is not known if the association reflects causality. We performed a cross-sectional study of 161 female participants included at Zealand University Hospital, Roskilde, Denmark. Data regarding basic demographics, infertility, pregnancies, sexual function, and known factors with impact on fertility was collected. Logistic regressions were performed to analyze the association between HS and infertility, adjusting for factors that influence fertility. The study population consisted of 55 patients with HS, 55 patients with other dermatological diseases (ODD), and 51 healthy controls (HC). The HS group had a higher BMI, lower sexual function, and a higher tobacco use. We found no significant difference between the three groups in terms of whether they had children, the number of children they had, infertility, or whether they had received fertility treatments. The logistic analyses found no correlation between HS and infertility, and adjusting for factors affecting infertility did not alter this result. This study did not find a significant difference in infertility between patients with HS compared to those with ODD or HC. This result was not affected by adjustments for other factors known to influence fertility. Interestingly, the lower sexual function in the HS group did not appear to influence their desire or ability to conceive.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，对生活质量有严重影响。其中一个方面是，HS 与不孕风险增加有关，但由于数据仍然有限，尚不清楚这种关联是否反映了因果关系。我们对丹麦罗斯基勒的 Zealand 大学医院的 161 名女性参与者进行了横断面研究。收集了有关基本人口统计学、不孕、妊娠、性功能以及已知对生育有影响的因素的数据。进行了逻辑回归分析，以调整影响生育的因素，来分析 HS 与不孕之间的关联。研究人群包括 55 名 HS 患者、55 名患有其他皮肤病（ODD）的患者和 51 名健康对照组（HC）。HS 组的 BMI 较高，性功能较低，吸烟率较高。在是否有孩子、孩子的数量、不孕或是否接受过生育治疗方面，三组之间没有显著差异。逻辑分析发现，HS 与不孕之间没有相关性，并且调整影响生育的因素也没有改变这一结果。本研究未发现 HS 患者与 ODD 或 HC 患者之间的不孕率存在显著差异。这一结果不受其他已知影响生育的因素的调整影响。有趣的是，HS 组性功能较低似乎并未影响他们的生育意愿或能力。
