Gupta A K, Haberman H F, Pawlowski D, Shulman G, Menon I A
Int J Dermatol. 1985 Oct;24(8):528-32. doi: 10.1111/j.1365-4362.1985.tb05839.x.
Canthaxanthin is used as a food-coloring agent, a photoprotective agent in certain photodermatoses, a tan-simulating agent, and a pigment to darken vitiliginous skin. This article reviews the current literature on canthaxanthin and reports the evaluation of oral canthaxanthin as an artificial pigment for the management of vitiligo. Fifty-six patients were studied, using serum canthaxanthin levels, pre- and post-treatment photographs with standard conditions, physician assessment, and patient questionnaires evaluating treatment results. Canthaxanthin was rated "very satisfactory" by 10%, "satisfactory" by 35%, and "unsatisfactory" by 54% of patients. In light-skinned individuals, self-reports were "very satisfactory" in 27%, "satisfactory" in 45%, and "unsatisfactory" in 27%. In dark-skinned individuals, the treatment was less effective. Women were happier with the results than men. Major side effects were red stools and orange palms and soles. Canthaxanthin can be taken orally, is easy to use, and can be a cosmetically acceptable therapy in selected cases of vitiligo.
角黄素可用作食品着色剂、某些光皮肤病的光保护剂、仿晒剂以及使白癜风皮肤变黑的色素。本文综述了关于角黄素的现有文献，并报告了口服角黄素作为治疗白癜风的人工色素的评估情况。对56例患者进行了研究，采用血清角黄素水平、标准条件下治疗前后的照片、医生评估以及评估治疗效果的患者问卷。10%的患者对角黄素评价为“非常满意”，35%评价为“满意”，54%评价为“不满意”。在浅肤色个体中，自我报告“非常满意”的占27%，“满意”的占45%，“不满意”的占27%。在深肤色个体中，治疗效果较差。女性对结果比男性更满意。主要副作用是大便发红以及手掌和脚底呈橙色。角黄素可口服，使用方便，在某些白癜风病例中可能是一种在美容方面可接受的疗法。
