Bogomolets National Medical University (NMU), 13, T. Shevchenko Blvd, Kyiv, 01601, Ukraine.
Research Center of Cancer, Shahid Beheshti University of Medical Sciences (SBUMS), Tehran, Iran.
J Health Popul Nutr. 2024 Sep 28;43(1):154. doi: 10.1186/s41043-024-00645-w.
Erectile dysfunction (ED) is a common condition with various contributing factors, including lifestyle and dietary habits. Caffeine, a widely consumed stimulant, has been linked to multiple physiological effects on vascular function and hormonal balance that might influence sexual function. This meta-analysis aims to evaluate the association between caffeine intake and the risk of ED by analyzing data from cohort studies.
A systematic search was conducted across PubMed, Web of Science, Scopus, and Embase databases, and a manual search was conducted on Google Scholar for studies on the relationship between caffeine intake and ED in adult men. The search included observational studies published up to April 1, 2024. Four cohort studies were included, and their data were extracted and analyzed by STATA version 18.
Four included cohort studies comprised 51,665 cohort members. The study population included adult males, on average, aged 18 to 80. The results indicate that there was no significant relationship between coffee consumption and the risk of ED (relative risk [RR] = 0.94, 95% CI: 0.86-1.03; p = 0.999).
The current evidence suggests no significant relationship between caffeine intake and ED, but limited studies limit conclusions. Future research should focus on larger sample sizes, standardized outcome assessments, and different dosages and forms of caffeine consumption.
勃起功能障碍（ED）是一种常见病症，有多种致病因素，包括生活方式和饮食习惯。咖啡因是一种广泛消费的兴奋剂，它对血管功能和激素平衡有多种生理影响，可能会影响性功能。本荟萃分析旨在通过分析队列研究的数据来评估咖啡因摄入与 ED 风险之间的关联。
通过对 PubMed、Web of Science、Scopus 和 Embase 数据库进行系统检索，并在 Google Scholar 上对咖啡因摄入与成年男性 ED 关系的研究进行手工检索，检索截至 2024 年 4 月 1 日的研究。纳入了关于咖啡因摄入与 ED 关系的观察性研究。使用 STATA 版本 18 提取和分析了四项队列研究的数据。
四项纳入的队列研究共包括 51665 名队列成员。研究人群平均年龄为 18 至 80 岁，均为成年男性。结果表明，咖啡消费与 ED 风险之间无显著关系（相对风险 [RR] = 0.94，95%CI：0.86-1.03；p = 0.999）。
目前的证据表明，咖啡因摄入与 ED 之间没有显著关系，但研究数量有限，限制了结论的得出。未来的研究应关注更大的样本量、标准化的结局评估，以及不同剂量和形式的咖啡因摄入。
