Mohapatra Arpita, Panda Akshyata, Pattnaik Naina, Mohapatra Madhumita, Singh Karandeep, Sharma Anant R, Sharma Nirvi, Makkad Ramanpal S
Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Science, KIIT Deemed to be University, Bhubaneswar, Odisha, India.
Department of Periodontics and Oral Implantology, Institute of Dental Sciences (IDS), S O A Deemed to be University, Bhubaneswar, Odisha, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S1965-S1967. doi: 10.4103/jpbs.jpbs_440_24. Epub 2024 Jun 7.
Periodontitis, a prevalent chronic inflammatory condition affecting the supporting structures of teeth, is closely associated with oxidative stress, characterized by an imbalance between reactive oxygen species generation and antioxidant defense mechanisms. Antioxidants have garnered significant attention as potential therapeutic agents in periodontal management due to their ability to counteract oxidative damage and inflammation. This brief review provides an overview of the role of antioxidants in periodontitis, highlighting recent developments. Key topics covered include the mechanisms of action of antioxidants, recent preclinical and clinical studies evaluating their efficacy, challenges, and future directions in antioxidant-based periodontal therapy. Recent advancements in antioxidant research offer promising avenues for improving periodontal treatment outcomes and patient care.
牙周炎是一种影响牙齿支持结构的常见慢性炎症性疾病,与氧化应激密切相关,其特征是活性氧生成与抗氧化防御机制之间失衡。抗氧化剂因其能够对抗氧化损伤和炎症,作为牙周治疗的潜在治疗剂受到了广泛关注。本简要综述概述了抗氧化剂在牙周炎中的作用,突出了近期的进展。涵盖的关键主题包括抗氧化剂的作用机制、评估其疗效的近期临床前和临床研究、挑战以及基于抗氧化剂的牙周治疗的未来方向。抗氧化剂研究的最新进展为改善牙周治疗效果和患者护理提供了有希望的途径。