Wei Xiang, Hormel Tristan T, Renner Laurie, Neuringer Martha, Jia Yali
Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA.
Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Biomed Opt Express. 2024 Jul 12;15(8):4642-4654. doi: 10.1364/BOE.525839. eCollection 2024 Aug 1.
Optical coherence tomography (OCT) is a well-established research tool for vision research in animal models capable of providing imaging of the retina. Structural OCT can be enhanced using OCT angiography (OCTA) processing in order to provide simultaneously acquired, automatically co-registered vascular information. Currently available OCT. Currently available OCTA lack either large field of view or high resolution. In this study we developed a wide-field (60-degree), high-resolution (10.5-µm optical transverse) and high-sensitivity (104-dB) OCTA-enabled system for non-human primate imaging and with it imaged multiple disease models, including models of age-related macular degeneration (AMD), Bardet-Biedl Syndrome (BBS), and the variant of Batten disease. We demonstrate clear visualization of features including drusen, ellipsoid zone loss, vascular retinopathy, and retinal thinning in these eyes.
光学相干断层扫描（OCT）是动物模型视觉研究中一种成熟的研究工具，能够对视网膜进行成像。通过光学相干断层扫描血管造影（OCTA）处理可以增强结构OCT，以便同时获取自动配准的血管信息。目前可用的OCT。目前可用的OCTA要么缺乏大视野，要么缺乏高分辨率。在本研究中，我们开发了一种用于非人灵长类动物成像的宽视野（60度）、高分辨率（光学横向分辨率10.5微米）和高灵敏度（104分贝）的具备OCTA功能的系统，并使用该系统对多种疾病模型进行成像，包括年龄相关性黄斑变性（AMD）、巴德-比埃尔综合征（BBS）和巴顿病变体模型。我们展示了在这些眼睛中包括玻璃膜疣、椭圆体带缺失、视网膜血管病变和视网膜变薄等特征的清晰可视化。
