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抗菌肽P113口腔护理产品在随机临床评估中对减少口腔细菌数量和牙菌斑形成的功效。

Efficacy of antimicrobial peptide P113 oral health care products on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment.

作者信息

Wu Yi-Fan, Han Bor-Cheng, Lin Wen-Yi, Wang Sin-Yu, Linn Thu Ya, Hsu Hsueh-Wen, Wen Chih-Chieh, Liu Hung-Yi, Chen Yi-Hua, Chang Wei-Jen

机构信息

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

Department of Biomedical Engineering, Ming-Chuan University, Taoyuan, Taiwan.

出版信息

J Dent Sci. 2024 Oct;19(4):2367-2376. doi: 10.1016/j.jds.2024.07.011. Epub 2024 Jul 19.

DOI:10.1016/j.jds.2024.07.011
PMID:39347072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11437278/
Abstract

BACKGROUND/PURPOSE: Dental plaque is the main cause leading to the dental caries and periodontal diseases. The main purpose of this study was to test the efficacy of oral spray containing the antimicrobial peptide P-113 on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment.

MATERIALS AND METHODS

This study was divided into two parts. In Part A, we investigated the user experiences with the P-113 containing oral spray. In part B, 14 subjects in the experimental group used the P-113-containing oral spray, while 14 subjects in the control group used a placebo without the P-113 in a 4-week clinical trial. Participants were asked to use the P-113-containing oral spray or placebo 3 times per day and 5 times per use. Moreover, 3 check-ups and 2 washouts were carried out to evaluate the DMFT score, dental plaque weight, dental plaque index, and gingival index.

RESULTS

In part A, up to 91.8% of the subjects in the experimental group were satisfied with the use of the P-113-containing oral spray. In part B, based on our PacBio SMRT sequencing platform and DADA2 analysis, the numbers of and in the experimental group were lower than those in the control group. In addition, decreased dental plaque weight, dental plaque index, and gingival index were all observed in the experimental group.

CONCLUSION

The P-113-containing oral spray has the potential to reduce the dental caries and periodontal disease-related bacteria and to control the dental plaque formation.

摘要

背景/目的：牙菌斑是导致龋齿和牙周疾病的主要原因。本研究的主要目的是在一项随机临床评估中测试含抗菌肽P-113的口腔喷雾剂在减少口腔细菌数量和牙菌斑形成方面的功效。

材料与方法

本研究分为两部分。在A部分，我们调查了含P-113口腔喷雾剂的用户体验。在B部分，14名实验组受试者使用含P-113的口腔喷雾剂，而14名对照组受试者在为期4周的临床试验中使用不含P-113的安慰剂。参与者被要求每天使用含P-113的口腔喷雾剂或安慰剂3次，每次使用5喷。此外，进行了3次检查和2次洗脱期，以评估龋失补牙面数（DMFT）评分、牙菌斑重量、牙菌斑指数和牙龈指数。

结果

在A部分，高达91.8%的实验组受试者对含P-113口腔喷雾剂的使用感到满意。在B部分，基于我们的PacBio SMRT测序平台和DADA2分析，实验组中[具体细菌名称1]和[具体细菌名称2]的数量低于对照组。此外，实验组的牙菌斑重量、牙菌斑指数和牙龈指数均有所下降。

结论

含P-113的口腔喷雾剂有潜力减少与龋齿和牙周疾病相关的细菌，并控制牙菌斑的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/f8b581c40e79/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/e98cb4f77291/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/5e0923224aa8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/3943a386baf2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/ae738722be6c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/62b0bfd0a714/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/3cba08ceea81/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/e557565f1f24/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/4f0bfa64f3bd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/dc6938ad1ae5/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/8790711ed760/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/f8b581c40e79/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/e98cb4f77291/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/5e0923224aa8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/3943a386baf2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/ae738722be6c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/62b0bfd0a714/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/3cba08ceea81/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/e557565f1f24/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/4f0bfa64f3bd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/dc6938ad1ae5/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/8790711ed760/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7861/11437278/f8b581c40e79/gr11.jpg

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