Jambholkar Pankaj C, Choudhari Sonali G, Sharma Mayank
Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.
Cureus. 2024 Aug 29;16(8):e68080. doi: 10.7759/cureus.68080. eCollection 2024 Aug.
Louis Pasteur is perhaps the most globally recognized French scientist. His groundbreaking discoveries in molecular chirality and advancements in fermentation greatly benefited brewers and winemakers. Pasteur introduced the process of pasteurization to sterilize wines and significantly contributed to the development of germ theory, which made Joseph Lister's antiseptic surgical techniques possible. Despite initially disproving Antoine Béchamp's theory that silkworm disease was caused by a microbial infection, Pasteur tackled this issue effectively. Building on the work of Henri Toussaint and Pierre Victor Galtier, he developed vaccines for pig erysipelas, chicken cholera, anthrax, and rabies. Pasteur also coined the term "vaccination," which Richard Dunning had used before Edward Jenner expanded upon it. Although Robert Koch criticized Pasteur's vaccination methods as ambiguous, historians have clarified many of the myths surrounding Pasteur. This review explores Pasteur's career, his undeniable achievements, and the realities behind the legendary figure who strove to make a significant impact on science and medicine.
路易·巴斯德或许是全球最广为人知的法国科学家。他在分子手性方面的开创性发现以及在发酵领域的进展极大地造福了啤酒酿造商和葡萄酒酿造商。巴斯德引入了巴氏杀菌法来对葡萄酒进行消毒,并为细菌学说的发展做出了重大贡献,这使得约瑟夫·李斯特的抗菌外科技术成为可能。尽管最初巴斯德反驳了安托万·贝尚的理论,即蚕病是由微生物感染引起的,但他有效地解决了这个问题。在亨利·图桑和皮埃尔·维克多·加尔捷的工作基础上,他研发出了针对猪丹毒、鸡霍乱、炭疽和狂犬病的疫苗。巴斯德还创造了“疫苗接种”这个术语,在爱德华·詹纳对其进行拓展之前,理查德·邓宁就已经使用过这个词。尽管罗伯特·科赫批评巴斯德的疫苗接种方法含糊不清,但历史学家已经澄清了许多围绕巴斯德的神话。这篇综述探讨了巴斯德的职业生涯、他不可否认的成就,以及这位努力在科学和医学领域产生重大影响的传奇人物背后的真实情况。