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一种非常通用的分子机器。

A very versatile molecular machine.

机构信息

Department of Biology, Texas A&M University, College Station, Texas, USA.

出版信息

J Bacteriol. 2024 Oct 24;206(10):e0035124. doi: 10.1128/jb.00351-24. Epub 2024 Sep 30.

DOI:10.1128/jb.00351-24
PMID:39347553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11500496/
Abstract

In this issue (J Bacteriol. 206: e0014024, https://doi.org/10.1128/jb.00140-24), Ridone and Baker describe hybrids between two 5:2 heteroheptameric ion-powered motors. Chimeras were constructed between stator units of a bacterial flagellum and ExbBD of the Ton outer-membrane transport system. Only one of the 14 hybrids supported swimming in . Three additional residue changes at sites distant from the hybrid region enhanced motility. This work suggests that flagellar stator units and ExbBD share an ancestor that diverged during evolution to perform different tasks.

摘要

在本期（《细菌学杂志》。206: e0014024，https://doi.org/10.1128/jb.00140-24）中，Ridone 和 Baker 描述了两种 5:2 异七聚体离子动力马达之间的杂种。在细菌鞭毛的定子单元和 Ton 外膜运输系统的 ExbBD 之间构建了嵌合体。只有 14 个杂种中的一个支持在. 中游泳。在远离杂交区域的位置的另外三个残基变化增强了运动性。这项工作表明，鞭毛定子单元和 ExbBD 共享一个祖先，该祖先在进化过程中分化以执行不同的任务。

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