Sato T, Oguma S, Yoshinaga K
Tohoku J Exp Med. 1985 Sep;147(1):89-96. doi: 10.1620/tjem.147.89.
Amino acid analysis was carried out on the acid hydrolyzate of the glomeruli isolated from the kidneys of 19 nondiabetic and 21 diabetic autopsy subjects. The glomeruli isolated from the diabetics were found to have a significant increase in their contents of amino acids such as hydroxyproline, glycine and hydroxylysine, when compared with nondiabetic controls. These changes were detected already in the diabetic cases with no apparent histological change, and were prominent in the glomeruli which had nodular lesion. A linear relationship was evident between the contents of hydroxyproline and hydroxylysine in the glomeruli isolated from all 40 subjects studied (y = 9.50 + 4.88x, r = 0.918, p less than 0.001). The values for the diabetic glomeruli showing diffuse lesion and nodular lesion scattered continuously along the same line. These results suggest that chemical character is almost same in the diabetic glomeruli with either diffuse lesion or nodular lesion.
对从19名非糖尿病和21名糖尿病尸检对象的肾脏中分离出的肾小球的酸水解产物进行了氨基酸分析。与非糖尿病对照组相比，发现从糖尿病患者分离出的肾小球中，羟脯氨酸、甘氨酸和羟赖氨酸等氨基酸含量显著增加。这些变化在没有明显组织学改变的糖尿病病例中就已被检测到，并且在有结节性病变的肾小球中更为突出。在研究的所有40名受试者分离出的肾小球中，羟脯氨酸和羟赖氨酸含量之间存在明显的线性关系（y = 9.50 + 4.88x，r = 0.918，p小于0.001）。显示弥漫性病变和结节性病变的糖尿病肾小球的值沿同一条线连续分布。这些结果表明，具有弥漫性病变或结节性病变的糖尿病肾小球的化学特征几乎相同。
