美洛西林与奈替米星在胆道手术中应用的前瞻性随机对照试验
A prospective randomised controlled trial of mezlocillin versus netilmicin in biliary surgery.
作者信息
Gillen P, Ryan W, Peel A L
出版信息
Ann R Coll Surg Engl. 1985 Nov;67(6):376-8.
A prospective randomised controlled trial of mezlocillin versus netilmicin in 133 patients undergoing biliary surgery at a district hospital is reported. Sixty-four patients received mezlocillin and 69 received netilmicin. The two groups of patients were comparable with regard to age, sex, underlying pathology and operative procedures performed. The incidence of infected bile at operation was 14.2% and both antibiotics were equally effective in reducing postoperative bacteraemia (0.75%) and wound infection (4.5%) to acceptable levels. It is concluded that netilmicin is a more cost-effective antibiotic in biliary surgery than mezlocillin.
本文报告了一项针对133例在地区医院接受胆道手术患者的前瞻性随机对照试验，比较了美洛西林与奈替米星的疗效。64例患者接受美洛西林治疗，69例患者接受奈替米星治疗。两组患者在年龄、性别、基础病理和手术操作方面具有可比性。手术时感染胆汁的发生率为14.2%，两种抗生素在将术后菌血症（0.75%）和伤口感染（4.5%）降低至可接受水平方面同样有效。结论是，在胆道手术中，奈替米星是一种比美洛西林更具成本效益的抗生素。
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