原发性胆汁性肝硬化女性中的乳腺癌
Breast cancer in women with primary biliary cirrhosis.
作者信息
Goudie B M, Burt A D, Boyle P, Macfarlane G, Birnie G G, Mills P R, Gillis C R, MacSween R N, Watkinson G
出版信息
Br Med J (Clin Res Ed). 1985 Dec 7;291(6509):1597-8. doi: 10.1136/bmj.291.6509.1597.
Abstract
The occurrence of extrahepatic malignancy was studied in 195 unselected patients who satisfied predetermined biochemical, immunological, and histological criteria for the diagnosis of primary biliary cirrhosis. The incidence of breast cancer in women with primary biliary cirrhosis was found to be significantly higher than in an age and sex matched control population from the same well defined geographical area (p less than 0.0015). The association of breast cancer and primary biliary cirrhosis remains unexplained, though diminished immunological surveillance, fat soluble vitamin deficiency, or endocrine dysfunction may play a part.
摘要
对195例未经过挑选的患者进行了肝外恶性肿瘤发生率的研究，这些患者符合原发性胆汁性肝硬化诊断的预定生化、免疫和组织学标准。结果发现，原发性胆汁性肝硬化女性患者的乳腺癌发病率显著高于来自同一明确地理区域的年龄和性别匹配的对照人群（p<0.0015）。乳腺癌与原发性胆汁性肝硬化之间的关联尚无法解释，不过免疫监视功能减弱、脂溶性维生素缺乏或内分泌功能障碍可能起到了一定作用。
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