Willets Katherine A
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States.
ACS Nano. 2024 Oct 15;18(41):27824-27832. doi: 10.1021/acsnano.4c10655. Epub 2024 Oct 1.
Super-resolution surface-enhanced Raman scattering (SERS) allows researchers to overcome the resolution limit of far field optical microscopy and peer into electromagnetic hot spots with nanoscale resolution. By localizing the signal from single (or few) molecules on the surface of plasmonic nanoparticle aggregates, relationships between the spatial origin of the SERS signal, local electromagnetic field enhancements, and SERS intensity can be determined. This Perspective describes the successes and challenges of super-resolution SERS, from the earliest mapping of single-molecule SERS hot spots to the current state-of-the-art, while highlighting open questions and future opportunities to advance the field. Comparisons with fluorescence-based super-resolution imaging are discussed to help frame the unique challenges associated with performing SERS in the super-resolution regime.
超分辨率表面增强拉曼散射（SERS）使研究人员能够克服远场光学显微镜的分辨率限制，并以纳米级分辨率窥视电磁热点。通过将来自单个（或少数）分子的信号定位在等离子体纳米颗粒聚集体的表面上，可以确定SERS信号的空间起源、局部电磁场增强与SERS强度之间的关系。本视角文章描述了超分辨率SERS的成功与挑战，从单分子SERS热点的最早映射到当前的技术水平，同时强调了推进该领域发展的开放性问题和未来机遇。文中还讨论了与基于荧光的超分辨率成像的比较，以帮助阐述在超分辨率领域进行SERS所面临的独特挑战。
