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氟代脱氧葡萄糖F18正电子发射断层扫描/计算机断层扫描中最大标准化摄取值与肿瘤大小的比值：非小细胞肺癌的一个简单预后参数。

Maximum standardized uptake value-to-tumor size ratio in fluorodeoxyglucose F18 positron emission tomography/computed tomography: a simple prognostic parameter for non-small cell lung cancer.

作者信息

Kim Soo Jeong, Lee Koeun, Lee Hyun Joo, Kang Du-Young, Kim Young Hwan

机构信息

Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine , Department of Nuclear Medicine, Seoul, Republic of Korea.

Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Department of Pathology, Seoul, Republic of Korea.

出版信息

Diagn Interv Radiol. 2025 Apr 28;31(3):274-279. doi: 10.4274/dir.2024.242837. Epub 2024 Oct 1.

DOI:10.4274/dir.2024.242837
PMID:39354721
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12057529/
Abstract

PURPOSE

By correcting the effect of tumor size on metabolic activity, the maximum standardized uptake value-to-tumor size (SUV:tumor size) ratio on fluorodeoxyglucose F18 positron emission tomography (F-FDG PET)/computed tomography (CT) scans can be a prognostic parameter of non-small cell lung cancer (NSCLC). The current study evaluates the prognostic value of SUV:tumor size ratio on pretreatment F-FDG PET/CT scans in patients with NSCLC. Furthermore, the SUV:tumor size ratio is compared with other established PET parameters.

METHODS

This study included 108 patients with NSCLC who underwent pretreatment F-FDG PET/CT scans and curative lung surgery. The associations between the SUV:tumor size ratio and other conventional PET parameters were investigated. The recurrence-free survival according to the SUV:tumor size ratio was also analyzed. In addition, the SUV:tumor size ratio was compared according to postoperative pathologic findings.

RESULTS

In total, 72 (66.7%) of the 108 participants presented with adenocarcinoma (ADC). Nineteen (17.6%) patients experienced recurrence during a median follow-up period of 32.3 months. The median SUV max:tumor size ratio was 2.37 (1.23 for ADCs and 3.90 for other histologic types). The SUV:tumor size ratio was associated with SUV and mean SUV, as well as metabolic tumor volume and total lesion glycolysis. Patients with an SUV:tumor size ratio higher than the median had a worse recurrence outcome than those with an SUV:tumor size ratio lower than the median. Participants with ADC who presented with lymphovascular invasion had a higher SUV:tumor size ratio than those without. The presence of lymph node metastasis and advanced histologic grade were associated with a high SUV:tumor size ratio in patients with ADC.

CONCLUSION

The SUV:tumor size ratio on pretreatment F-FDG PET/CT scans was associated with aggressive tumor behavior and poor outcome in NSCLCs, particularly ADC.

CLINICAL SIGNIFICANCE

The SUV:tumor size ratio on pretreatment F-FDG PET/CT scans has a prognostic value in patients with NSCLCs, especially ADC.

摘要

目的

通过校正肿瘤大小对代谢活性的影响，氟代脱氧葡萄糖F18正电子发射断层扫描（F-FDG PET）/计算机断层扫描（CT）上的最大标准化摄取值与肿瘤大小（SUV:肿瘤大小）之比可作为非小细胞肺癌（NSCLC）的一个预后参数。本研究评估SUV:肿瘤大小比在NSCLC患者治疗前F-FDG PET/CT扫描中的预后价值。此外，将SUV:肿瘤大小比与其他已确立的PET参数进行比较。

方法

本研究纳入了108例行治疗前F-FDG PET/CT扫描及根治性肺手术的NSCLC患者。研究了SUV:肿瘤大小比与其他传统PET参数之间的关联。还分析了根据SUV:肿瘤大小比的无复发生存情况。此外，根据术后病理结果比较了SUV:肿瘤大小比。

结果

108名参与者中共有72名（66.7%）患有腺癌（ADC）。19名（17.6%）患者在中位随访期32.3个月内出现复发。SUV最大值与肿瘤大小之比的中位数为2.37（ADC为1.23，其他组织学类型为3.90）。SUV:肿瘤大小比与SUV、平均SUV以及代谢肿瘤体积和总病变糖酵解相关。SUV:肿瘤大小比高于中位数的患者的复发结局比低于中位数的患者更差。出现脉管侵犯的ADC参与者的SUV:肿瘤大小比高于未出现者。淋巴结转移和高级别组织学分级与ADC患者的高SUV:肿瘤大小比相关。

结论

治疗前F-FDG PET/CT扫描上的SUV:肿瘤大小比与NSCLC，尤其是ADC的侵袭性肿瘤行为和不良结局相关。

临床意义

治疗前F-FDG PET/CT扫描上的SUV:肿瘤大小比在NSCLC患者，尤其是ADC患者中具有预后价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/a24488e19f3e/DiagnIntervRadiol-31-3-274-figure-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/6c5601c0a743/DiagnIntervRadiol-31-3-274-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/a27267680f5e/DiagnIntervRadiol-31-3-274-figure-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/c6936b62af9a/DiagnIntervRadiol-31-3-274-figure-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/04997b97612a/DiagnIntervRadiol-31-3-274-figure-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/a24488e19f3e/DiagnIntervRadiol-31-3-274-figure-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/6c5601c0a743/DiagnIntervRadiol-31-3-274-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/a27267680f5e/DiagnIntervRadiol-31-3-274-figure-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/c6936b62af9a/DiagnIntervRadiol-31-3-274-figure-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/04997b97612a/DiagnIntervRadiol-31-3-274-figure-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8527/12057529/a24488e19f3e/DiagnIntervRadiol-31-3-274-figure-5.jpg

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