Minakata H, Komura H, Tamura S Y, Ohfune Y, Nakanishi K, Kada T
Experientia. 1985 Dec 15;41(12):1622-3. doi: 10.1007/BF01964840.
Five unusual amino acids were identified as antimutagens against spontaneous mutation of Salmonella typhimurium TA100: L-azetidine-2-carboxylic acid (1) from Liliaceae plants, alpha-(methylenecyclopropyl)glycine (2) from Litchi chinensis seeds, and 2-amino-4-methylhex-5-ynoic acid (3), hypoglycin A (4), and (2S,4R)-2-amino-4-hydroxyhept-6-ynoic acid (5) from Euphoria longana seeds. The absolute stereochemistry of 5 was determined by its chiral synthesis from L-allylglycine, proving that 5 is the C-4 epimer of the amino acid previously isolated from dried longan seeds.
已鉴定出五种不同寻常的氨基酸可作为鼠伤寒沙门氏菌TA100自发突变的抗诱变剂：来自百合科植物的L-氮杂环丁烷-2-羧酸（1）、来自荔枝种子的α-（亚甲基环丙基）甘氨酸（2），以及来自龙眼种子的2-氨基-4-甲基己-5-炔酸（3）、降血糖素A（4）和（2S,4R）-2-氨基-4-羟基庚-6-炔酸（5）。通过从L-烯丙基甘氨酸进行手性合成确定了5的绝对立体化学结构，证明5是先前从干龙眼种子中分离出的氨基酸的C-4差向异构体。
