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载有阿霉素的双刺激响应性智能纳米聚合物的合成、表征及抗癌作用

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers.

作者信息

Acet Ömür, Kirsanov Pavel, Önal Acet Burcu, Halets-Bui Inessa, Shcharbin Dzmitry, Ceylan Cömert Şeyda, Odabaşı Mehmet

机构信息

Vocational School of Health Science, Pharmacy Services Program, Tarsus University, Tarsus, Turkey.

Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Minsk, Belarus.

出版信息

Beilstein J Nanotechnol. 2024 Sep 26;15:1189-1196. doi: 10.3762/bjnano.15.96. eCollection 2024.

DOI:10.3762/bjnano.15.96
PMID:39355301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11443663/
Abstract

Nanopolymers represent a significant group of delivery vehicles for hydrophobic drugs. In particular, dual stimuli-responsive smart polymer nanomaterials might be extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smart nanopolymers (DOX-SNPs) were produced. Characterizations of the synthesized nanostructures were carried out including zeta potential measurements, Fourier-transform infrared spectroscopy, and scanning electron microscopy. The loading capacity of the nanopolymers for DOX was investigated, and encapsulation and release studies were carried out. In a final step, the cytotoxicity of the DOX-nanopolymer complexes against the HeLa cancer cell line at different concentrations and incubation times was studied. The DOX release depended on temperature and pH value of the release medium, with the highest release at pH 6.0 and 41 °C. This effect was similar to that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smart nanopolymers can be efficiently used to create new types of doxorubicin-based drugs.

摘要

纳米聚合物是疏水性药物的一类重要递送载体。特别是，双刺激响应型智能聚合物纳米材料在药物递送和释放方面可能极为有用。我们分析了将具有抗有丝分裂和抗增殖作用的已知抗肿瘤药物阿霉素（DOX）纳入纳米聚合物复合物中的可能性。因此，制备了负载阿霉素的温度和pH敏感型智能纳米聚合物（DOX-SNPs）。对合成的纳米结构进行了表征，包括zeta电位测量、傅里叶变换红外光谱和扫描电子显微镜。研究了纳米聚合物对DOX的负载能力，并进行了包封和释放研究。在最后一步中，研究了DOX-纳米聚合物复合物在不同浓度和孵育时间下对HeLa癌细胞系的细胞毒性。DOX的释放取决于释放介质的温度和pH值，在pH 6.0和41°C时释放量最高。这种效应与阿霉素商业脂质体制剂Doxil所观察到的效应相似。所得结果表明，智能纳米聚合物可有效地用于制造新型基于阿霉素的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/9ee64459b3c0/Beilstein_J_Nanotechnol-15-1189-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/8e60da3ea51c/Beilstein_J_Nanotechnol-15-1189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/a765850c5eb5/Beilstein_J_Nanotechnol-15-1189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/675907d1f6fc/Beilstein_J_Nanotechnol-15-1189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/0d14d9f0718f/Beilstein_J_Nanotechnol-15-1189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/2341a6586c6a/Beilstein_J_Nanotechnol-15-1189-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/9ee64459b3c0/Beilstein_J_Nanotechnol-15-1189-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/8e60da3ea51c/Beilstein_J_Nanotechnol-15-1189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/a765850c5eb5/Beilstein_J_Nanotechnol-15-1189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/675907d1f6fc/Beilstein_J_Nanotechnol-15-1189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/0d14d9f0718f/Beilstein_J_Nanotechnol-15-1189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/2341a6586c6a/Beilstein_J_Nanotechnol-15-1189-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3331/11443663/9ee64459b3c0/Beilstein_J_Nanotechnol-15-1189-g007.jpg

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