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Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration.

作者信息

Li Zimu, Shan Xiaoting, Chen Zhidong, Gao Nansha, Zeng Wenfeng, Zeng Xiaowei, Mei Lin

机构信息

Institute of Pharmaceutics School of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Shenzhen 518107 China.

Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192 China.

出版信息

Adv Sci (Weinh). 2020 Nov 27;8(1):2002589. doi: 10.1002/advs.202002589. eCollection 2020 Jan.

DOI:10.1002/advs.202002589
PMID:33437580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7788636/
Abstract

The impermeable barrier of solid tumors due to the complexity of their components limits the treatment effect of nanomedicine and hinders its clinical translation. Several methods are available to increase the penetrability of nanomedicine, yet they are too complex to be effective, operational, or practical. Surface modification employs the characteristics of direct contact between multiphase surfaces to achieve the most direct and efficient penetration of solid tumors. Furthermore, their simple operation makes their use feasible. In this review, the latest surface modification strategies for the penetration of nanomedicine into solid tumors are summarized and classified into "bulldozer strategies" and "mouse strategies." Additionally, the evaluation methods, existing problems, and the development prospects of these technologies are discussed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/c0b6fd3baeb2/ADVS-8-2002589-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/dcfb525851df/ADVS-8-2002589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/6fa7f06b0775/ADVS-8-2002589-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/c97e50a05ea6/ADVS-8-2002589-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/a7fa9244c466/ADVS-8-2002589-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/72284f1189d0/ADVS-8-2002589-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/277c421d33b7/ADVS-8-2002589-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/13eae9b090cc/ADVS-8-2002589-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/1d005be2cbf1/ADVS-8-2002589-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/92125f1efee2/ADVS-8-2002589-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/68a6ce32b9bb/ADVS-8-2002589-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/a66d7a8504dc/ADVS-8-2002589-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/6f3c42c73ccf/ADVS-8-2002589-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/c0b6fd3baeb2/ADVS-8-2002589-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/dcfb525851df/ADVS-8-2002589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/6fa7f06b0775/ADVS-8-2002589-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/c97e50a05ea6/ADVS-8-2002589-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/a7fa9244c466/ADVS-8-2002589-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/72284f1189d0/ADVS-8-2002589-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/277c421d33b7/ADVS-8-2002589-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/13eae9b090cc/ADVS-8-2002589-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/1d005be2cbf1/ADVS-8-2002589-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/92125f1efee2/ADVS-8-2002589-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/68a6ce32b9bb/ADVS-8-2002589-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/a66d7a8504dc/ADVS-8-2002589-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/6f3c42c73ccf/ADVS-8-2002589-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823c/7788636/c0b6fd3baeb2/ADVS-8-2002589-g013.jpg

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本文引用的文献

[1]
Nanoparticle-based drug delivery systems for cancer therapy.

Smart Mater Med. 2020

[2]
Size and charge dual-transformable mesoporous nanoassemblies for enhanced drug delivery and tumor penetration.

Chem Sci. 2020-2-3

[3]
Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model.

Adv Mater Interfaces. 2020-4-21

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Mussel-Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment.

Macromol Biosci. 2020-10

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Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy.

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