Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
The First Clinical Medical Academy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
J Affect Disord. 2023 Nov 15;341:358-365. doi: 10.1016/j.jad.2023.08.140. Epub 2023 Sep 4.
The use of specific dietary patterns to alleviate depressive symptoms has gained increasing recognition. The Composite Dietary Antioxidant Index (CDAI) is a crucial criterion for assessing antioxidant diets. We examined the relationship between CDAI and depression among overweight and obese adults through a cross-sectional study conducted in the United States.
We used weighted multivariate logistic regression models with subgroup analysis to study the relationship between CDAI and depression. Generalized additive models were used to determine whether there was a nonlinear association between them. We developed a two-piece linear regression model to calculate the inflection point utilizing a recursive strategy.
After adjusting for confounding variables, the odds ratios (ORs; 95 % CI) for the correlation between CDAI and depression were 0.75 (0.67, 0.84). A saturation effect emerged for the overweight group, following which we calculated the inflection point for the overweight population, which displayed ORs (95 % CI) of 0.62 (0.47, 0.80) before the inflection point of 0.83 and the ORs (95 % CI) of 1.01 (0.77, 1.31) after 0.83. The interaction was statistically significant in the sex stratification of the obese population.
Our study highlighted a negative association between CDAI and depression among overweight and obese adults. Saturation effects and sex differences were observed in the overweight population.
使用特定的饮食模式来缓解抑郁症状已经得到越来越多的认可。复合膳食抗氧化指数（CDAI）是评估抗氧化饮食的重要标准。我们通过在美国进行的横断面研究，考察了 CDAI 与超重和肥胖成年人抑郁之间的关系。
我们使用加权多变量逻辑回归模型进行亚组分析，研究 CDAI 与抑郁之间的关系。使用广义加性模型确定它们之间是否存在非线性关系。我们采用递归策略开发了两段线性回归模型来计算拐点。
在调整了混杂变量后，CDAI 与抑郁之间的比值比（OR；95%CI）为 0.75（0.67，0.84）。超重组出现饱和效应，之后我们计算了超重人群的拐点，在拐点 0.83 之前的 OR（95%CI）为 0.62（0.47，0.80），在 0.83 之后的 OR（95%CI）为 1.01（0.77，1.31）。肥胖人群的性别分层中，交互作用具有统计学意义。
我们的研究强调了超重和肥胖成年人中 CDAI 与抑郁之间的负相关关系。在超重人群中观察到饱和效应和性别差异。
