三级医疗中心慢性肝病患者中的肝细胞癌：一项描述性横断面研究
Hepatocellular Carcinoma among Patients with Chronic Liver Disease in a Tertiary Care Centre: A Descriptive Cross-sectional Study.
作者信息
Gnawali Arun, Pathak Rahul, Koirala Dinesh, Pandey Rajesh, Hamal Rabin, Jha Anurag, Kafle Bhandari Brindeswari, Gyawali Siddinath
机构信息
Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
出版信息
JNMA J Nepal Med Assoc. 2024 Feb 29;62(271):165-169. doi: 10.31729/jnma.8488.
INTRODUCTION
Hepatocellular carcinoma is the most common primary liver cancer. Viral hepatitis, alcohol abuse, and autoimmune hepatitis are the common causes of hepatocellular carcinoma. Usually patients present at advanced stages where curative treatment is no longer possible. This study aimed to find the prevalence of hepatocellular carcinoma among patients with chronic liver disease in a tertiary care centre.
METHODS
This is a descriptive cross-sectional study conducted in a single tertiary care centre from March 2020 to August 2022. The study was done among inpatients of the Department of Gastroenterology after ethical approval from the Institutional Review Committee. A total population sampling method was used and data were collected using predetermined proformas. Point estimate at 95% Confidence Interval was calculated.
RESULTS
Among 1440 patients, hepatocellular carcinoma was seen in 54 (3.75%) (2.77-4.73, 95% Confidence Interval). At the time of diagnosis, 48 (88.89%) were symptomatic. The presenting symptoms were weight loss seen in 35 (64.81%) being the most common. Out of them, 37 (68.52%) consumed alcohol and 40 (74.07%) smoked cigarettes.
CONCLUSIONS
Hepatocellular carcinoma is a notable concern. Alcohol-related liver cirrhosis is the most frequent condition encountered in patients with hepatocellular carcinoma in our setting.
引言
肝细胞癌是最常见的原发性肝癌。病毒性肝炎、酗酒和自身免疫性肝炎是肝细胞癌的常见病因。通常患者就诊时已处于晚期，无法进行根治性治疗。本研究旨在确定一家三级医疗中心慢性肝病患者中肝细胞癌的患病率。
方法
这是一项描述性横断面研究，于2020年3月至2022年8月在一家单一的三级医疗中心进行。该研究在获得机构审查委员会伦理批准后，对胃肠病科住院患者开展。采用总体抽样方法，并使用预先确定的表格收集数据。计算95%置信区间的点估计值。
结果
在1440例患者中，有54例（3.75%）（2.77 - 4.73，95%置信区间）被诊断为肝细胞癌。诊断时，48例（88.89%）有症状。最常见的症状是体重减轻，35例（64.81%）出现该症状。其中，37例（68.52%）饮酒，40例（74.07%）吸烟。
结论
肝细胞癌是一个值得关注的问题。在我们的研究环境中，酒精性肝硬化是肝细胞癌患者中最常见的情况。
Zotero 插件