Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, 999077, PR China.
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, 999077, PR China.
Biomaterials. 2025 Mar;314:122857. doi: 10.1016/j.biomaterials.2024.122857. Epub 2024 Sep 28.
Ultrasound, as a form of mechanical energy, possesses a distinctive ability to deeply penetrate tissues, allowing for non-invasive manipulation of cellular activities. Utilizing nanomaterials in conjunction with ultrasound has enabled simple, efficient, spatiotemporally controllable, and minimally invasive regulation of cellular activities with ultrasound-generated electric, optical, acoustic, or chemical stimuli at the localized nanomaterials interface. This technology allows for precise and localized regulation of cellular activities, which is essential for studying and understanding complex biological processes, and also provides new opportunities for research, diagnostics, and therapeutics in the fields of biology and medicine. In this article, we review the state-of-the-art and ongoing developments in nanomaterials-enabled ultrasound cellular modulation, highlighting potential applications and advancements achieved through the integration of sono-responsive nanomaterials with ultrasound.
超声作为一种机械能，具有独特的穿透组织的能力，可实现对细胞活动的非侵入性操控。将纳米材料与超声结合使用，可以在纳米材料界面处利用超声产生的电、光、声或化学刺激，实现简单、高效、时空可控且微创的细胞活动调控。这项技术可实现对细胞活动的精确和局部调控，对于研究和理解复杂的生物学过程至关重要，同时也为生物学和医学领域的研究、诊断和治疗提供了新的机会。本文综述了基于纳米材料的超声细胞调制的最新进展和研究现状，重点介绍了通过将声响应纳米材料与超声结合所取得的潜在应用和进展。
