Toxicology Research Laboratory, Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India.
Post Graduate Department of Zoology, A. B. N. Seal College, Cooch Behar, West Bengal, India.
Sci Total Environ. 2024 Dec 1;954:176547. doi: 10.1016/j.scitotenv.2024.176547. Epub 2024 Sep 30.
Parabens are globally employed as important preservatives in pharmaceutical, food, and personal care products. Nonetheless, improper disposal of commercial products comprising parabens can potentially contaminate various environmental components, including the soil and water. Residues of parabens have been detected in surface water, ground water, packaged food materials, and other consumer items. Long-term exposure to parabens through numerous consumer products and contaminated water can harm human health. Paraben can modulate the hormonal and immune orchestra of the body. Recent findings have correlated paraben use with hypersensitivity, obesity, and infertility. Notably, parabens have also been detected in the samples of breast cancer patients, suggesting a potential cross-talk between parabens and carcinogenesis. Therefore, the present article aims to dissect the significance of parabens as a preservative in several consumer products and their impact of chronic exposure to human health. This review encompasses various facets of paraben, including its sources, mechanism of action at the molecular level, and sheds light on its toxicological implications on human health.
对羟基苯甲酸酯作为一种重要的防腐剂，被广泛应用于医药、食品和个人护理产品中。然而，含对羟基苯甲酸酯的商业产品如果处理不当，可能会污染包括土壤和水在内的各种环境成分。对羟基苯甲酸酯残留已在地表水、地下水、包装食品材料和其他消费品中被检测到。通过众多消费品和受污染的水长期接触对羟基苯甲酸酯会对人类健康造成危害。对羟基苯甲酸酯可以调节人体的激素和免疫系统。最近的研究发现，对羟基苯甲酸酯的使用与过敏、肥胖和不孕有关。值得注意的是，对羟基苯甲酸酯也在乳腺癌患者的样本中被检测到，这表明对羟基苯甲酸酯与致癌作用之间可能存在相互作用。因此，本文旨在探讨对羟基苯甲酸酯作为几种消费品中防腐剂的意义及其对人类健康的慢性暴露影响。本文综述了对羟基苯甲酸酯的各个方面，包括其来源、在分子水平上的作用机制，并探讨了其对人类健康的毒理学意义。
