Gou Meng, Wang Xiaxia, Duan Xuyuan, Wang Yaocen, Pang Yue, Dong Yonghui
Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Sci Data. 2024 Oct 2;11(1):1075. doi: 10.1038/s41597-024-03925-6.
As one of the two most ancient groups of extant vertebrates, lamprey has become an important model organism in various fields of biology. In this paper, we present a comprehensive tissue-wide spatial metabolomics dataset for lampreys, where 14 distinct tissues were analyzed using liquid chromatography-mass spectrometry (LC-MS) in both positive and negative ion modes. The dataset has been fully validated using internal standard and pooled quality control samples and is readily accessible at the UCSD Metabolomics Workbench. This dataset serves as a valuable resource for researchers using lampreys as a model organism. Additionally, it acts as a benchmark metabolomics dataset for evaluating new algorithms and software tools and comparing them with previously published results. A lamprey spatial metabolomics database is also provided to support studies utilizing lampreys as an animal model, and to complement and validate other spatial metabolomics studies on lampreys conducted with mass spectrometry imaging or other techniques.
作为现存的两个最古老的脊椎动物类群之一，七鳃鳗已成为生物学各个领域的重要模式生物。在本文中，我们展示了一个全面的七鳃鳗全组织空间代谢组学数据集，其中使用液相色谱 - 质谱联用（LC-MS）在正离子和负离子模式下对14种不同组织进行了分析。该数据集已使用内标和混合质量控制样品进行了全面验证，并且可以在加州大学圣地亚哥分校代谢组学工作台轻松获取。该数据集为将七鳃鳗用作模式生物的研究人员提供了宝贵资源。此外，它还作为一个基准代谢组学数据集，用于评估新的算法和软件工具，并将它们与以前发表的结果进行比较。还提供了一个七鳃鳗空间代谢组学数据库，以支持将七鳃鳗用作动物模型的研究，并补充和验证其他使用质谱成像或其他技术进行的七鳃鳗空间代谢组学研究。
