Naderi Alireza, Mozaffarpur Seyyed Ali, Shirafkan Hoda, Bayani Masomeh, Memariani Zahra
Student Research Center, Babol University of Medical Sciences, Babol, Iran.
Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2024 Sep 7;15(4):651-658. doi: 10.22088/cjim.15.4.651. eCollection 2024 Fall.
Treatments for acute bronchitis is usually a supportive care to relieve upper respiratory symptoms. This study aimed to evaluate the effect of syrup (PMS) on cough severity in acute bronchitis.
Patients (20-75 years-old) referred to the clinic of infectious diseases in Ayatollah Rouhani Hospital, Babol, Iran with a complaint of cough and the Bronchitis Severity Scale (BSS) ≥5 entered the study. The patients randomly received PMS or placebo 30 ml/day for 10 days. Patients were visited before treatment and on days 5 and 10 after treatment. The primary outcome was BSS score and secondary outcome was the life quality that was measured by means of the Persian version of the Leicester Cough Questionnaire (LCQ) at the first visit and on the 10 day.
Of the 121 patients diagnosed with acute bronchitis, 80 eligible patients (42.87±11.75 years-old) were randomly divided into PMS and placebo groups. The BSS score in the PMS group after 10 days was significantly lower than that of the placebo group (P=0.001). Frequency of cough (P=0.001), sputum production (P=0.005), and chest wall pain (P=0.008) were significantly lower in the PMS group than in the placebo group. In terms of quality of life, all items, including psychological, physical, and social domains, as well as total scores, were altered significantly in the PMS group compared to placebo. During monitoring of side effects, no significant adverse effects were stated in either group.
The study indicates the palliative effects of PMS in relieving the symptoms of acute bronchitis and improving quality of life.
急性支气管炎的治疗通常是缓解上呼吸道症状的支持性护理。本研究旨在评估糖浆（PMS）对急性支气管炎咳嗽严重程度的影响。
年龄在20 - 75岁、因咳嗽前来伊朗巴博勒阿亚图拉·鲁哈尼医院传染病诊所就诊且支气管炎严重程度量表（BSS）≥5的患者纳入研究。患者随机接受PMS或安慰剂，每日30毫升，共10天。在治疗前以及治疗后第5天和第10天对患者进行访视。主要结局是BSS评分，次要结局是生活质量，在首次就诊时和第10天通过波斯语版的莱斯特咳嗽问卷（LCQ）进行测量。
在121例被诊断为急性支气管炎的患者中，80例符合条件的患者（年龄42.87±11.75岁）被随机分为PMS组和安慰剂组。10天后，PMS组的BSS评分显著低于安慰剂组（P = 0.001）。PMS组的咳嗽频率（P = 0.001）、痰液产生（P = 0.005）和胸壁疼痛（P = 0.008）显著低于安慰剂组。在生活质量方面，与安慰剂相比，PMS组在心理、身体和社会领域的所有项目以及总分均有显著变化。在监测副作用期间，两组均未报告明显的不良反应。
该研究表明PMS在缓解急性支气管炎症状和改善生活质量方面具有姑息作用。
