Gharaei Nejad Kaveh, Darjani Abbas, Alizadeh Narges, Hakemzadeh Seyede Tahoura, Hassanzadeh Rad Afagh, Kazemnejad-Leili Ehsan, Ghadarjani Reyhaneh, Eftekhari Hojat, Rafiei Rana, Dalili Setila
Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Caspian J Intern Med. 2024 Sep 7;15(4):659-665. doi: 10.22088/cjim.15.4.659. eCollection 2024 Fall.
Acne vulgaris is a chronic, inflammatory disease and one of the most common skin diseases. Isotretinoin is the best treatment for severe nodulocystic acne compared to other systemic medicine. Although serum lipids elevation is one of the side effects of this medicine; recent studies have shown controversial results. This study aimed to assess the serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.
This is a cross-sectional study on 65 adolescents and adults older than 16 years old (55 females and 10 males) with moderate to severe degrees of acne vulgaris under a fixed low dose of 20 mg/day Isotretinoin treatment for 120 days. We analyzed the data using the SPSS software Version 16 using paired sample t-test, Wilcoxon, and ANCOVA test.
In this study, 65 records of patients with a mean age of 22.21±6.25 years were assessed. There was a significant elevation in Cholesterol and LDL levels, but in HDL and triglyceride levels no significant change occurred. A significant change in cholesterol levels was noticed in the adolescent age group, the female sex, and the normal weight group. Triglyceride had a significant change in the female sex and normal weight group and HDL significantly increased in male patients.
Although a low dose of isotretinoin can be used with minimal concern for changes in lipid profile in acne vulgaris patients, in the long-term follow-up and treatment, it seems that we have to administer it cautiously.
寻常痤疮是一种慢性炎症性疾病，也是最常见的皮肤病之一。与其他全身性药物相比，异维A酸是治疗重度结节囊肿性痤疮的最佳药物。尽管血清脂质升高是该药的副作用之一，但最近的研究结果存在争议。本研究旨在评估接受异维A酸治疗的寻常痤疮青少年和成人的血清脂质谱。
这是一项横断面研究，对65名16岁以上的青少年和成人（55名女性和10名男性）进行，他们患有中度至重度寻常痤疮，接受固定低剂量20毫克/天的异维A酸治疗120天。我们使用SPSS软件16版，通过配对样本t检验、威尔科克森检验和协方差分析来分析数据。
在本研究中，评估了65例平均年龄为22.21±6.25岁患者的记录。胆固醇和低密度脂蛋白水平显著升高，但高密度脂蛋白和甘油三酯水平无显著变化。在青少年年龄组、女性和正常体重组中，胆固醇水平有显著变化。甘油三酯在女性和正常体重组中有显著变化，男性患者的高密度脂蛋白显著升高。
尽管低剂量异维A酸可用于寻常痤疮患者，对脂质谱变化的担忧最小，但在长期随访和治疗中，似乎仍需谨慎使用。
