Youdim M B, Yehuda S
Peptides. 1985 Sep-Oct;6(5):851-5. doi: 10.1016/0196-9781(85)90313-4.
Rats made nutritionally iron-deficient (ID) have significantly diminished haemoglobin, serum iron and hypothermic response to d-amphetamine (15 mg/kg). The reduction of d-amphetamine induced hypothermia is comparatively greater in the dark than in the light period. Neither TRH (1 mg/kg) nor CG 3703, a peptidase resistant TRH analogue (1 mg/kg), induced hypothermia in control of ID animals. However, in combination with d-amphetamine, TRH and CG 3703 did not alter the hypothermic effect observed initially with d-amphetamine. In contrast to control animals, ID rats treated with saline or d-amphetamine (15 mg/kg) exhibited a greater degree of motor activity in the light as compared to the dark period. However, the overall activity (light plus dark) was unchanged in the ID group. The motor activity in response to TRH or CG 3703 was not changed as a result of iron-deficiency. These differential responses may be due to a more pronounced action of d-amphetamine on dopaminergic system, which is known to be changed in iron-deficiency, and of TRH and CG 3703 on the noradrenergic neurones.
营养性缺铁（ID）的大鼠血红蛋白、血清铁显著降低，对右旋苯丙胺（15毫克/千克）的体温降低反应也明显减弱。右旋苯丙胺诱导的体温降低在黑暗期比在光照期的降幅更大。促甲状腺激素释放激素（TRH，1毫克/千克）和一种抗肽酶的TRH类似物CG 3703（1毫克/千克）在对照动物和ID动物中均未诱导体温降低。然而，与右旋苯丙胺联合使用时，TRH和CG 3703并未改变最初观察到的右旋苯丙胺的体温降低效应。与对照动物不同，用生理盐水或右旋苯丙胺（15毫克/千克）处理的ID大鼠在光照期的运动活动程度比黑暗期更大。然而，ID组的总体活动（光照期加黑暗期）没有变化。缺铁并未改变对TRH或CG 3703的运动反应。这些不同的反应可能是由于右旋苯丙胺对多巴胺能系统的作用更为显著（已知缺铁会改变该系统），以及TRH和CG 3703对去甲肾上腺素能神经元的作用。
