Yehuda S, Youdim M B
Peptides. 1981 Summer;2(2):131-5. doi: 10.1016/s0196-9781(81)80024-1.
TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar to its effect in control intact rats, but PS-24 induced marked hypothermia in hypophysectomized rats. While TRH partially blocked d-amphetamine-induced hypothermia, PS-24 induced marked hypothermia in hypophysectomized rats. While TRH partially blocked d-amphetamine-induced hypothermia were blocked in olfactory tubercle-lesioned rats. The data indicate that the thermal effects of PS-24 are mediated by the dopaminergic neurons in the nucleus accumbens and are reversible by pretreatment with haloperidol in hypophysectomized rats. In addition, no correlation between the effects of the treatments on thermoregulation and motor activity was found.
促甲状腺激素释放激素（TRH）和PS - 24（一种抗TRH肽酶的类似物）对置于4摄氏度环境下的大鼠的体温和运动活动产生不同影响。PS - 24可导致体温过低，但TRH不会。PS - 24可引起运动亢进，而TRH则引起轻微运动减退。TRH对垂体切除大鼠的热效应与其对完整对照大鼠的效应相似，但PS - 24在垂体切除大鼠中可导致明显的体温过低。虽然TRH可部分阻断右旋苯丙胺诱导的体温过低，但PS - 24在垂体切除大鼠中可导致明显的体温过低。而TRH部分阻断右旋苯丙胺诱导的体温过低在嗅结节损伤的大鼠中被阻断。数据表明，PS - 24的热效应由伏隔核中的多巴胺能神经元介导，并且在垂体切除大鼠中通过氟哌啶醇预处理可逆转。此外，未发现这些处理对体温调节和运动活动的影响之间存在相关性。
