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基于基因影像诊断的 SEZ6L2 过表达与癌症免疫浸润

Overexpression of SEZ6L2 and Immune Infiltration in Cancer Based on Gene Image Diagnosis.

机构信息

Department of General Surgery, Chongming Branch of Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Department of Thyroid and Breast, Division of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

Skin Res Technol. 2024 Oct;30(10):e70096. doi: 10.1111/srt.70096.

DOI:10.1111/srt.70096
PMID:39360664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11447639/
Abstract

BACKGROUND

With the rapid advancement of optical image diagnostic technology, researchers are delving into the potential applications in the field of cancer diagnosis and treatment. The exact link between the SEZ6L2 gene and cancer immune infiltration remains elusive.

MATERIALS AND METHODS

This study aims to investigate the relationship between SEZ6L2 gene overexpression and cancer immune infiltration using optical image diagnostic technology, thereby presenting novel insights for enhancing cancer diagnosis and treatment strategies. Tissue samples obtained from cancer patients were meticulously analyzed to quantitatively assess the expression of the SEZ6L2 gene through light image diagnostic technology. Additionally, immunohistochemical techniques were employed to assess the nature and quantity of immune infiltrating cells within the cancerous tissues.

RESULTS

The enrichment pathways were found to include complement activation, circulating immunoglobulin mediated humoral immune response, protein activation cascade, immunoglobulin complex, and immunoglobulin. In addition, the expression of SEZ6L2 is closely related to the infiltration level of tumor infiltrating immune cells (TIICs), and there is a potential relationship between the expression of SEZ6L2 and different marker genes of TIIC.

CONCLUSION

Increased SEZ6L2 mRNA expression in breast invasive carcinoma was significantly associated with negative prognosis and immune invasion. SEZ6L2 may be a novel prognostic biomarker and a potential immunotherapeutic target in BRCA.

摘要

背景

随着光学图像诊断技术的快速发展，研究人员正在深入研究其在癌症诊断和治疗领域的潜在应用。SEZ6L2 基因与癌症免疫浸润的确切联系仍不清楚。

材料和方法

本研究旨在利用光学图像诊断技术研究 SEZ6L2 基因过表达与癌症免疫浸润的关系，为增强癌症诊断和治疗策略提供新的见解。通过光图像诊断技术，对癌症患者的组织样本进行了仔细分析，以定量评估 SEZ6L2 基因的表达。此外，还采用免疫组织化学技术评估了癌组织中免疫浸润细胞的性质和数量。

结果

富集途径包括补体激活、循环免疫球蛋白介导的体液免疫反应、蛋白质激活级联、免疫球蛋白复合物和免疫球蛋白。此外，SEZ6L2 的表达与肿瘤浸润免疫细胞（TIIC）的浸润水平密切相关，SEZ6L2 的表达与 TIIC 的不同标记基因之间存在潜在关系。

结论

在乳腺浸润性癌中，SEZ6L2 mRNA 表达的增加与不良预后和免疫浸润显著相关。SEZ6L2 可能是 BRCA 中的一种新的预后生物标志物和潜在的免疫治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/9a20b93ad389/SRT-30-e70096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/0b84b937a114/SRT-30-e70096-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/622c5b963055/SRT-30-e70096-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/ef752beb856b/SRT-30-e70096-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/6f6a72959dfc/SRT-30-e70096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/1ca83685589d/SRT-30-e70096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/c350e624a702/SRT-30-e70096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/9a20b93ad389/SRT-30-e70096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/0b84b937a114/SRT-30-e70096-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/622c5b963055/SRT-30-e70096-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/ef752beb856b/SRT-30-e70096-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/b0054110e662/SRT-30-e70096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/6f6a72959dfc/SRT-30-e70096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/1ca83685589d/SRT-30-e70096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/c350e624a702/SRT-30-e70096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c1a/11447639/9a20b93ad389/SRT-30-e70096-g001.jpg

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本文引用的文献

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Indian J Cancer. 2022 Jul-Sep;59(3):438-439. doi: 10.4103/ijc.IJC_83_21.
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Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature.副肿瘤性小脑综合征中的抗SEZ6L2抗体：病例报告及文献综述
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Sez6l2-associated encephalitis in a patient with small-cell lung cancer.一名小细胞肺癌患者的Sez6l2相关性脑炎
白细胞介素-4与特应性皮炎：为何重要？一篇叙述性综述。
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SEZ6L2, regulated by USF1, accelerates the growth and metastasis of breast cancer.SEZ6L2 在 USF1 的调控下促进乳腺癌的生长和转移。
Exp Cell Res. 2022 Aug 1;417(1):113194. doi: 10.1016/j.yexcr.2022.113194. Epub 2022 May 4.
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High expression of as an independent prognostic Indicator in thyroid carcinoma.作为甲状腺癌独立预后指标的高表达。 （注：原文中“as an independent prognostic Indicator in thyroid carcinoma”前面缺少具体的表达内容，比如某个基因、蛋白等的高表达，这里翻译是按照补充完整后的意思来呈现的，原英文表述不太完整规范）
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Cancer statistics, 2022.癌症统计数据，2022 年。
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