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The acute periventricular injury syndrome: a possible animal model for psychotic disease.

作者信息

Kline J, Reid K H

出版信息

Psychopharmacology (Berl). 1985;87(3):292-7. doi: 10.1007/BF00432710.

DOI:10.1007/BF00432710
PMID:3936084
Abstract

A new experimental brain syndrome involving localized periventricular damage induced by intracerebroventricular injections of lysophosphatidyl choline has been developed in adult rats. The acute periventricular injury syndrome is characterized by transient weight loss, decreased emotionality, extreme postural indifference (catalepsy), inappropriate aggressive responses, impaired grooming, cerebral ventricular enlargement, and periventricular damage to both cells and fiber sheaths. This syndrome appears to simulate several features of schizophrenia, and it may prove useful in the study of psychotic disorders in man.

摘要

相似文献

1
The acute periventricular injury syndrome: a possible animal model for psychotic disease.
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2
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3
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本文引用的文献

1
Interhemispheric transfer of stereognostic information in chronic schizophrenics.
Br J Psychiatry. 1980 Jan;136:53-8. doi: 10.1192/bjp.136.1.53.
2
Impaired speed of information processing in nonmedicated schizotypal patients.未服药的分裂型人格障碍患者信息处理速度受损。
Schizophr Bull. 1981;7(3):499-508. doi: 10.1093/schbul/7.3.499.
3
Hemispheric asymmetries in schizophrenia.精神分裂症中的半球不对称性。
Biol Psychiatry. 1981 Jun;16(6):561-82.
4
Neuropathology of schizophrenia.精神分裂症的神经病理学
Arch Gen Psychiatry. 1982 Oct;39(10):1131-9. doi: 10.1001/archpsyc.1982.04290100011003.
5
Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms.精神分裂症中的脑室扩大：与阳性和阴性症状的关系。
Am J Psychiatry. 1982 Mar;139(3):297-302. doi: 10.1176/ajp.139.3.297.
6
Cerebral ventricular enlargement in subtypes of chronic schizophrenia.慢性精神分裂症亚型中的脑室扩大
Arch Gen Psychiatry. 1982 Jul;39(7):774-7. doi: 10.1001/archpsyc.1982.04290070010003.
7
Possible defects of interhemispheric integration in children of schizophrenics.精神分裂症患者子女大脑半球间整合的潜在缺陷。
J Nerv Ment Dis. 1983 Jul;171(7):421-5. doi: 10.1097/00005053-198307000-00005.
8
Corpus callosum thickness in chronic schizophrenia.慢性精神分裂症患者的胼胝体厚度
Br J Psychiatry. 1983 Mar;142:284-7. doi: 10.1192/bjp.142.3.284.
9
Ventricular enlargement in child psychiatric patients: a controlled study with planimetric measurements.儿童精神科患者的脑室扩大：一项采用面积测量法的对照研究。
Am J Psychiatry. 1983 Apr;140(4):453-6. doi: 10.1176/ajp.140.4.453.
10
Central brain morphology in chronic schizophrenic patients: a controlled CT study.慢性精神分裂症患者的脑中央形态：一项CT对照研究。
Biol Psychiatry. 1983 Oct;18(10):1133-40.