Panayi Peter, Peters Emmanuelle, Bentall Richard, Hardy Amy, Berry Katherine, Sellwood William, Dudley Robert, Longden Eleanor, Underwood Raphael, Steel Craig, Jafari Hassan, Emsley Richard, Mason Liam, Elliott Rebecca, Varese Filippo
Division of Psychology and Mental Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
Complex Trauma and Resilience Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK.
Psychol Med. 2024 Oct 4;54(12):1-12. doi: 10.1017/S0033291724001934.
Post-traumatic stress disorder (PTSD) has been shown to predict psychotic symptomology. However, few studies have examined the relative contribution of PTSD compared to broader post-traumatic sequelae in maintaining psychosis. Complex PTSD (cPTSD), operationalized using ICD-11 criteria, includes core PTSD (intrusions, avoidance, hyperarousal) as well as additional "disturbances of self-organisation" (DSO; emotional dysregulation, interpersonal difficulties, negative self-concept) symptoms, more likely to be associated with complex trauma histories. It was hypothesized that DSOs would be associated with positive psychotic symptoms (paranoia, voices, and visions) in daily life, over and above core PTSD symptoms.
This study ( = 153) employed a baseline subsample of the Study of Trauma And Recovery (STAR), a clinical sample of participants with comorbid post-traumatic stress and psychosis symptoms. Core PTSD, DSO and psychosis symptoms were assessed up to 10 times per day at quasi-random intervals over six consecutive days using Experience Sampling Methodology.
DSOs within the preceding 90 min predicted paranoia, voices, and visions at subsequent moments. These relationships persisted when controlling for core PTSD symptoms within this timeframe, which were themselves significant. The associations between DSOs and paranoia but not voices or visions, were significantly stronger than those between psychosis and core PTSD symptoms.
Consistent with an affective pathway to psychosis, the findings suggest that DSOs may be more important than core PTSD symptoms in maintaining psychotic experiences in daily life among people with comorbid psychosis and cPTSD, and indicate the potential importance of addressing broad post-traumatic sequelae in trauma-focused psychosis interventions.
创伤后应激障碍(PTSD)已被证明可预测精神病症状。然而,与更广泛的创伤后后遗症相比,很少有研究考察PTSD在维持精神病方面的相对作用。复杂性创伤后应激障碍(cPTSD),按照国际疾病分类第11版标准进行界定,包括核心PTSD(侵入性症状、回避症状、过度警觉)以及额外的“自我组织障碍”(DSO;情绪失调、人际关系困难、消极自我概念)症状,这些症状更可能与复杂的创伤史相关。研究假设,在核心PTSD症状之外,DSO与日常生活中的阳性精神病症状(偏执、幻听和幻视)相关。
本研究(n = 153)采用了创伤与恢复研究(STAR)的基线子样本,该样本为患有创伤后应激和精神病共病症状的临床样本。使用经验取样法,在连续六天内,以准随机间隔每天对核心PTSD、DSO和精神病症状进行多达10次评估。
前90分钟内的DSO可预测随后时刻的偏执、幻听和幻视。在控制该时间段内的核心PTSD症状后,这些关系依然存在,而核心PTSD症状本身也具有显著影响。DSO与偏执之间的关联(而非与幻听或幻视的关联)显著强于精神病与核心PTSD症状之间的关联。
与精神病的情感通路一致,研究结果表明,在患有精神病和cPTSD的人群中,DSO在维持日常生活中的精神病体验方面可能比核心PTSD症状更重要,并表明在以创伤为重点的精神病干预中解决广泛的创伤后后遗症具有潜在重要性。