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韩国犬源耐碳青霉烯类 的流行情况和分子特征。

Prevalence and molecular characteristics of carbapenem-resistant isolated from dogs in South Korea.

机构信息

Bacterial Disease Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.

Division of Health Hazard Response, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.

出版信息

J Vet Sci. 2024 Sep;25(5):e67. doi: 10.4142/jvs.24164.

DOI:10.4142/jvs.24164
PMID:39363655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11450394/
Abstract

IMPORTANCE

Carbapenem-resistant are emerging as a global public health risk. Therefore, assessing the prevalence of carbapenem-resistant (CRE) in both humans and animals is important.

OBJECTIVE

We aimed to ascertain the occurrence and characteristics of CRE isolated from companion animals, dogs and cats.

METHODS

strains were tested for antimicrobial susceptibility using the broth microdilution technique. Antimicrobial resistance genes were detected by polymerase chain reaction and sequencing analysis. The molecular characteristics of CRE were determined using multi-locus sequence typing, replicon typing, and pulsed-field gel electrophoresis (PFGE).

RESULTS

In total, 13 CRE isolates (0.13%) were identified from dogs possessing along with β-lactamase genes, mostly (92.2%) and (53.8%). The commonly observed mutations were S83L and D87N in , S80I in , and S458A in . CRE carried non-beta-lactam resistance genes, with the majority being (B) (100%), (84.6%), and (53.8%). Nine different PFGE patterns (P1-P9), IncX3-type plasmids (69.2%), and ST410 (84.6%) were predominantly detected.

CONCLUSIONS AND RELEVANCE

This investigation provides significant insight into the prevalence and molecular characteristics of -carrying in dogs. The co-existence of and other antimicrobial resistance genes in potentially poses severe health hazards to humans.

摘要

重要性

耐碳青霉烯肠杆菌正在成为全球公共卫生的一个风险。因此，评估人类和动物中耐碳青霉烯肠杆菌 (CRE) 的流行情况很重要。

目的

我们旨在确定从伴侣动物（狗和猫）中分离出的 CRE 的发生和特征。

方法

使用肉汤微量稀释技术测试菌株对抗菌药物的敏感性。通过聚合酶链反应和测序分析检测抗菌药物耐药基因。使用多位点序列分型、复制子分型和脉冲场凝胶电泳 (PFGE) 确定 CRE 的分子特征。

结果

总共从具有 blaCTX-M-15 基因的狗中鉴定出 13 株 CRE 分离株（0.13%），这些基因主要是 blaCTX-M-15（92.2%）和 blaOXA-48-like（53.8%）。常见的突变是 blaCTX-M-15 中的 S83L 和 D87N，blaOXA-48-like 中的 S80I，和 blaNDM-1 中的 S458A。CRE 携带非β-内酰胺类耐药基因，其中大多数是 blaCTX-M-15（100%），blaTEM-1（84.6%）和 blaOXA-48-like（53.8%）。主要检测到 9 种不同的 PFGE 模式（P1-P9）、IncX3 型质粒（69.2%）和 ST410（84.6%）。

结论和相关性

这项调查提供了关于狗中携带 blaCTX-M-15 基因的 CRE 流行情况和分子特征的重要见解。 在 中同时存在 blaCTX-M-15 和其他抗菌药物耐药基因可能对人类健康构成严重威胁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1064/11450394/cc0ff27bcb95/jvs-25-e67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1064/11450394/cc0ff27bcb95/jvs-25-e67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1064/11450394/cc0ff27bcb95/jvs-25-e67-g001.jpg

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本文引用的文献

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Antibiotics (Basel). 2023 Dec 27;13(1):27. doi: 10.3390/antibiotics13010027.
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Prevalence and Characterization of Extended-Spectrum β-Lactamase-Producing Isolated from Dogs and Cats in South Korea.韩国犬猫中分离出的产超广谱β-内酰胺酶菌株的流行情况及特征
Antibiotics (Basel). 2023 Apr 13;12(4):745. doi: 10.3390/antibiotics12040745.
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A Cross-Sectional Study of Companion Animal-Derived Multidrug-Resistant Escherichia coli in Hangzhou, China.
中国杭州宠物源多重耐药性大肠杆菌的横断面研究
Microbiol Spectr. 2023 Feb 22;11(2):e0211322. doi: 10.1128/spectrum.02113-22.
4
Molecular epidemiology and genomic insights into the transmission of carbapenem-resistant NDM-producing .耐碳青霉烯类且产新德里金属β-内酰胺酶（NDM）菌株传播的分子流行病学及基因组学见解
Comput Struct Biotechnol J. 2023 Jan 9;21:847-855. doi: 10.1016/j.csbj.2023.01.004. eCollection 2023.
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Molecular and clinical characteristics of carbapenem-resistant Enterobacteriaceae isolates collected at a tertiary hospital in northern China.中国北方一家三甲医院碳青霉烯类耐药肠杆菌科细菌的分子和临床特征。
Trans R Soc Trop Med Hyg. 2023 Jan 3;117(1):55-57. doi: 10.1093/trstmh/trac059.
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Comparative genomic analysis of plasmids encoding metallo-β-lactamase NDM-5 in Enterobacterales Korean isolates from companion dogs.对来自伴侣犬的韩国肠杆菌科分离株中编码金属β-内酰胺酶NDM-5的质粒进行比较基因组分析。
Sci Rep. 2022 Jan 28;12(1):1569. doi: 10.1038/s41598-022-05585-1.
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