School of Biomedical Engineering, Institute for Advanced Study, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, P. R. China.
Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China.
Anal Chem. 2024 May 28;96(21):8713-8720. doi: 10.1021/acs.analchem.4c00960. Epub 2024 May 14.
Ketogenic diets have attracted substantial interest in the treatment of chronic diseases, but there are health risks with long-term regimes. Despite the advancements in diagnostic and therapeutic methods in modern medicine, there is a huge gap in personalized health management of this dietary strategy. Hence, we present a wearable microneedle biosensor for real-time ketone and glucose monitoring. The microneedle array possesses excellent mechanical properties, allowing for consistent sampling of interstitial biomarkers while reducing the pain associated with skin puncture. Vertical graphene with outstanding electrical conductivity provides the resulting sensor with a high sensitivity of 234.18 μA mM cm and a low limit detection of 1.21 μM. When this fully integrated biosensor was used in human volunteers, it displayed an attractive analytical capability for tracking the dynamic metabolite levels. Moreover, the results of the on-body evaluation established a significant correlation with commercial blood measurements. Overall, this cost-effective and efficient sensing platform can accelerate the application of a ketogenic diet in personal nutrition and wellness management.
生酮饮食在慢性疾病治疗方面引起了广泛关注，但长期实施存在健康风险。尽管现代医学在诊断和治疗方法上取得了进步，但在这种饮食策略的个性化健康管理方面仍存在巨大差距。因此，我们提出了一种用于实时酮体和葡萄糖监测的可穿戴微针生物传感器。微针阵列具有优异的机械性能，可在减少皮肤穿刺疼痛的同时实现间质生物标志物的持续采样。具有卓越导电性的垂直石墨烯为传感器提供了 234.18 μA mM cm 的高灵敏度和 1.21 μM 的低检测限。当将这种完全集成的生物传感器用于人类志愿者时，它显示出了用于跟踪动态代谢物水平的有吸引力的分析能力。此外，体内评估结果与商业血液测量结果建立了显著相关性。总的来说，这种具有成本效益和高效率的传感平台可以加速生酮饮食在个人营养和健康管理中的应用。
