Tian Cuihong, Zhang Xuan, Tang Haoxian, Luo Nan, Huang Jingtao, Lin Hanyuan, Yang Qinglong, Chen Yequn, Tan Xuerui
Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
Human Phenome Institute of Shantou University Medical College, Guangdong Engineering Research Center of Human Phenome, Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong, 515063, China.
BMC Public Health. 2025 May 17;25(1):1829. doi: 10.1186/s12889-025-23067-7.
Aortic aneurysm is one of the causes of cardiovascular disease-related death, posing a significant challenge to global healthcare. Understanding the burden of aortic aneurysm is crucial for formulating effective public health intervention policies and allocating resources. The study aims to assess the global, regional, and national burden, trend, and inequalities of aortic aneurysm.
Aortic aneurysm-associated mortality, disability-adjusted life-years (DALYs), age-standardized mortality rate (ASMR), age-standardized disability-adjusted life-years (ASDR), and their average annual percentage change (AAPC) were estimated based on a population-based study, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. The global, regional, and national burden of aortic aneurysm was analyzed across 204 countries and territories from 1990 to 2021, stratified by sex, sociodemographic index (SDI), and further predicted to 2045.
The ASMR decreased from 2.54 per 100,000 population in 1990 to 1.86 per 100,000 population in 2021, with an AAPC of -0.99%. The ASDR declined from 48.79 per 100,000 population in 1990 to 36.54 per 100,000 population in 2021, with an AAPC of -0.90%. The most significant decline in ASDR was observed among males (-1.14% vs. -0.68% per year). ASMR increased considerably, especially in countries with a low-middle SDI (1.29% per year), while it dropped particularly in countries with a high SDI (-1.65% per year). Notably, though the number of mortality and DALYs was predicted to continue rising, the ASMR and ASDR for aortic aneurysm were projected to decrease annually from, with predicted values of 1.92 per 100,000 population and 40.38 per 100,000 population in 2045, respectively.
The global relative burden of individuals with aortic aneurysm decreased since 1990, along with a prominent decrease in related ASMR and ASDR. Aortic aneurysm-related mortality and DALYs were higher in males and those living in regions with a high SDI.
主动脉瘤是心血管疾病相关死亡的原因之一，给全球医疗保健带来重大挑战。了解主动脉瘤的负担对于制定有效的公共卫生干预政策和资源分配至关重要。本研究旨在评估主动脉瘤的全球、区域和国家负担、趋势及不平等情况。
基于一项基于人群的研究——《2021年全球疾病、伤害及风险因素负担研究》（GBD 2021），估计了与主动脉瘤相关的死亡率、伤残调整生命年（DALYs）、年龄标准化死亡率（ASMR）、年龄标准化伤残调整生命年（ASDR）及其年均百分比变化（AAPC）。分析了1990年至2021年期间204个国家和地区的主动脉瘤全球、区域和国家负担，按性别、社会人口指数（SDI）分层，并进一步预测至2045年。
年龄标准化死亡率从1990年的每10万人2.54例降至2021年的每10万人1.86例，年均百分比变化为-0.99%。年龄标准化伤残调整生命年从1990年的每10万人48.79例降至2021年的每10万人36.54例，年均百分比变化为-0.90%。年龄标准化伤残调整生命年下降最显著的是男性（每年-1.14%对-0.68%）。年龄标准化死亡率有显著上升，特别是在中低社会人口指数的国家（每年1.29%），而在高社会人口指数的国家则显著下降（每年-1.65%）。值得注意的是，尽管预计死亡人数和伤残调整生命年数量将继续上升，但主动脉瘤的年龄标准化死亡率和年龄标准化伤残调整生命年预计将逐年下降，2045年的预测值分别为每10万人1.92例和每10万人40.38例。
自1990年以来，主动脉瘤患者的全球相对负担有所下降，相关的年龄标准化死亡率和年龄标准化伤残调整生命年也显著下降。主动脉瘤相关的死亡率和伤残调整生命年在男性以及生活在高社会人口指数地区的人群中更高。
