Guilbaud G, Iggo A
Exp Brain Res. 1985;61(1):164-8. doi: 10.1007/BF00235631.
Joint capsule mechanoreceptors in arthritic rats are more sensitive to pressure than similar receptors in normal animals. This greater sensitivity was reversed by the intravenous or topical administration of lysine acetylsalicylate in anaesthetised rats in doses of 15 to 50 mgm ASA-equivalent/kg. The reduction in sensitivity began within 5-10 min and reached a minimum mean value of 35% of the control after 35 to 40 min. During this period there was a negative linear or exponential relation between the amplitude of response to a controlled mechanical stimulus and time after administration of lysine acetylsalicylate. Control values of sensitivity were reached about 65-70 min following treatment with lysine acetylsalicylate. The results are interpreted as indicating that the high sensitivity of the arthritic joint capsule receptors is due to locally produced prostaglandins, such as prostacyclin.
与正常动物的类似受体相比，关节炎大鼠的关节囊机械感受器对压力更为敏感。在麻醉大鼠中，静脉注射或局部施用剂量为15至50毫克阿司匹林当量/千克的赖氨酸乙酰水杨酸酯可逆转这种更高的敏感性。敏感性降低在5 - 10分钟内开始，35至40分钟后达到对照值的最低平均值35%。在此期间，对受控机械刺激的反应幅度与赖氨酸乙酰水杨酸酯给药后的时间呈负线性或指数关系。赖氨酸乙酰水杨酸酯治疗后约65 - 70分钟达到敏感性对照值。结果表明，关节炎关节囊受体的高敏感性是由局部产生的前列腺素，如前列环素所致。
