De Castro Costa Mauricio, De Sutter Paul, Gybels Jan, Van Hees Johan
Department of Neurology and Neurosurgery, University of Louvain, B-3000 Louvain Belgium.
Pain. 1981 Apr;10(2):173-185. doi: 10.1016/0304-3959(81)90193-7.
Adjuvant-induced arthritic rats were observed clinically and behaviorally. The clinical disease has a duration of greater than 1 month and can be divided into a pre-clinical (1-10 days), an acute (15-30 days), postacute (30-50 days) and a late phase (greater than 50 days). Adjuvant arthritis induces significantly quantitatively changes in the rats' behaviour. Two types of behavioural change merit special attention: freezing (arresting) and scratching. Freezing is significantly increased in the acute and postacute phases; it is increased by morphine, this effect being blocked by naloxone. Scratching is significantly increased in the acute, postacute and late phases; it is decreased by morphine, this effect being blocked by naloxone. The chronic presence of scratching, and the effects of morphine and naloxone on it, allow us to consider it as a possible pain-rated behaviour and therefore as a possible parameter for the study of chronic pain in animals.
对佐剂诱导的关节炎大鼠进行了临床和行为观察。临床疾病持续时间超过1个月，可分为临床前期（1 - 10天）、急性期（15 - 30天）、急性后期（30 - 50天）和后期（超过50天）。佐剂性关节炎在大鼠行为上引起显著的定量变化。有两种行为变化值得特别关注：僵住（静止不动）和抓挠。僵住在急性期和急性后期显著增加；吗啡可使其增加，这种作用可被纳洛酮阻断。抓挠在急性期、急性后期和后期显著增加；吗啡可使其减少，这种作用可被纳洛酮阻断。抓挠的长期存在以及吗啡和纳洛酮对其的影响，使我们可以将其视为一种可能的疼痛相关行为，因此可作为研究动物慢性疼痛的一个可能参数。
