Kursawe Larsen Christoffer, Schwensen Jakob F B, Zachariae Claus, Svedman Cecilia, Johansen Jeanne D, Bergendorff Ola
Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, Hellerup, Denmark.
Faculty of Health Science, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Contact Dermatitis. 2025 Feb;92(2):131-136. doi: 10.1111/cod.14709. Epub 2024 Oct 5.
Rubber gloves contain rubber accelerators that may cause contact allergy. The content of sensitising rubber accelerators in contemporary rubber gloves is not well known.
Identify and quantify the content of rubber accelerators in disposable rubber gloves.
Fifty-one gloves of 49 different brands were collected. Forty-eight of the gloves were disposable and three re-usable. The gloves were analysed for their content of sensitising rubber accelerators, that is, zinc dithiocarbamates, thiurams, thiazoles/benzothiazoles, diphenylguanidine, and thioureas by high-performance liquid chromatography.
Rubber accelerators were identified in 43/48 (90%) of the disposable gloves. In total, 39 gloves contained zinc dibutyldithiocarbamate (ZDBC) (0.18-1.96 mg/g), 34 zinc diethyldithiocarbamate (ZDEC) (0.032-2.78 mg/g), three zinc dibenzyldithiocarbamate (0.65-1.4 mg/g), one zinc dimethyldithiocarbamate (0.23 mg/g), and one 1,3-diphenylguanidine (0.21 mg/g). 2-cyanoethyl dimethyldithiocarbamate (CEDMC) was identified in three gloves (<0.052 mg/g). The one glove labelled as accelerator free contained ZDBC (1.07 mg/g). Only few glove packages had the specific content of rubber accelerators labelled.
The most frequent rubber accelerators in rubber gloves are ZDEC and ZDBC. Accelerator-free gloves may contain rubber accelerators. Full labelling of rubber gloves is needed and producers should be sure not to falsely claim that the rubber gloves are free of rubber accelerators.
橡胶手套含有可能引起接触性过敏的橡胶促进剂。目前尚不清楚当代橡胶手套中致敏橡胶促进剂的含量。
鉴定并量化一次性橡胶手套中橡胶促进剂的含量。
收集了49个不同品牌的51只手套。其中48只为一次性手套，3只为可重复使用手套。通过高效液相色谱法分析手套中致敏橡胶促进剂的含量，即二硫代氨基甲酸锌、秋兰姆、噻唑/苯并噻唑、二苯基胍和硫脲。
在48只一次性手套中的43只（90%）检测到橡胶促进剂。总共39只手套含有二丁基二硫代氨基甲酸锌（ZDBC）（0.18 - 1.96毫克/克），34只含有二乙基二硫代氨基甲酸锌（ZDEC）（0.032 - 2.78毫克/克），3只含有二苄基二硫代氨基甲酸锌（0.65 - 1.4毫克/克），1只含有二甲基二硫代氨基甲酸锌（0.23毫克/克），1只含有1,3 - 二苯基胍（0.21毫克/克）。在3只手套中检测到2 - 氰基乙基二甲基二硫代氨基甲酸酯（CEDMC）（<0.052毫克/克）。那只标记为无促进剂的手套含有ZDBC（1.07毫克/克）。只有少数手套包装标明了橡胶促进剂的具体含量。
橡胶手套中最常见的橡胶促进剂是ZDEC和ZDBC。无促进剂手套可能含有橡胶促进剂。橡胶手套需要完整标注，生产商应确保不虚假宣称橡胶手套不含橡胶促进剂。
