Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China; Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, Center for Infectious Disease Research, School of Medicine, Westlake University, Hangzhou, China.
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China; NHC Key Laboratory of Public Nutrition and Health, Beijing, China.
Cell Rep Med. 2024 Oct 15;5(10):101775. doi: 10.1016/j.xcrm.2024.101775. Epub 2024 Oct 4.
The dynamics of the gut mycobiome and its association with cardiometabolic health remain largely unexplored. Here, we employ internal transcribed spacer (ITS) sequencing to capture the gut mycobiome composition and dynamics within a nationwide human cohort of 12,641 Chinese participants, including 1,946 participants with repeated measurements across three years. We find that the gut mycobiome is associated with cardiometabolic diseases and related biomarkers in both cross-sectional and dynamic analyses. Fungal alpha diversity indices and 19 mycobiome genera are the major contributors to the mycobiome-cardiometabolic disease link. Particularly, Saccharomyces emerges as an effect modifier of traditional risk factors in promoting type 2 diabetes risk. Further integration of multi-omics data reveals key metabolites such as γ-linolenic acid and L-valine linking the gut mycobiome to type 2 diabetes. This study advances our understanding of the potential roles of the gut mycobiome in cardiometabolic health.
肠道微生物组的动态及其与心脏代谢健康的关联在很大程度上仍未得到探索。在这里，我们采用内部转录间隔区（ITS）测序技术，在一个由 12641 名中国参与者组成的全国性人类队列中，包括 1946 名参与者在三年内进行了三次重复测量，以捕获肠道微生物组的组成和动态。我们发现，肠道微生物组与横断面和动态分析中的心脏代谢疾病和相关生物标志物有关。真菌 alpha 多样性指数和 19 个微生物组属是微生物组-心脏代谢疾病联系的主要贡献者。特别地，酿酒酵母作为促进 2 型糖尿病风险的传统危险因素的效应修饰因子出现。进一步整合多组学数据揭示了关键代谢物，如γ-亚麻酸和 L-缬氨酸，将肠道微生物组与 2 型糖尿病联系起来。这项研究增进了我们对肠道微生物组在心脏代谢健康中的潜在作用的理解。
