Niu Xiaodong, Zhang Yan, Wang Yuan
Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Cancer Pathog Ther. 2023 Nov 7;2(4):219-230. doi: 10.1016/j.cpt.2023.11.002. eCollection 2024 Oct.
Glioma is the most prevalent primary malignant tumor in the central nervous system (CNS). It represents a diverse group of brain malignancies characterized by the presence of various cancer cell types as well as an array of noncancerous cells, which together form the intricate glioma tumor microenvironment (TME). Understanding the interactions between glioma cells/glioma stem cells (GSCs) and these noncancerous cells is crucial for exploring the pathogenesis and development of glioma. To invesigate these interactions requires co-culture models that closely mirror the actual TME . In this review, we summarize the two- and three-dimensional co-culture model systems for glioma-TME interactions currently available. Furthermore, we explore common glioma-TME cell interactions based on these models, including interactions of glioma cells/GSCs with endothelial cells/pericytes, microglia/macrophages, T cells, astrocytes, neurons, or other multi-cellular interactions. Together, this review provides an update on the glioma-TME interactions, offering insights into glioma pathogenesis.
神经胶质瘤是中枢神经系统（CNS）中最常见的原发性恶性肿瘤。它是一类多样的脑恶性肿瘤，其特征是存在各种癌细胞类型以及一系列非癌细胞，这些细胞共同构成了复杂的神经胶质瘤肿瘤微环境（TME）。了解神经胶质瘤细胞/神经胶质瘤干细胞（GSCs）与这些非癌细胞之间的相互作用对于探索神经胶质瘤的发病机制和发展至关重要。要研究这些相互作用需要能够紧密模拟实际TME的共培养模型。在这篇综述中，我们总结了目前可用的用于神经胶质瘤-TME相互作用的二维和三维共培养模型系统。此外，我们基于这些模型探索常见的神经胶质瘤-TME细胞相互作用，包括神经胶质瘤细胞/GSCs与内皮细胞/周细胞、小胶质细胞/巨噬细胞、T细胞、星形胶质细胞、神经元的相互作用，或其他多细胞相互作用。总之，这篇综述提供了关于神经胶质瘤-TME相互作用的最新信息，为神经胶质瘤的发病机制提供了见解。
