Voss Daniel, Wemmer Clara, Leonhardt Steffen, Walter Marian
Chair for Medical Information Technology, RWTH Aachen University, Aachen, Germany.
J Electr Bioimpedance. 2024 Oct 5;15(1):130-136. doi: 10.2478/joeb-2024-0015. eCollection 2024 Jan.
Cardiovascular diseases are a leading cause of mortality worldwide. Thus, critically ill patients require continuous monitoring of cardiovascular indicators, such as the left ventricular volume (LVV). Although continuous hemodynamic monitoring of patients is desirable, due to technical limitations, current measurement technologies either require manual intervention of the physician or only provide inaccurate results. Intracardiac impedance measurements are a promising approach for continuous assessment of cardiac function. However, developing and evaluating these methods requires a simulation model of the left ventricle with cardiac motion during an entire cardiac cycle. While many models exist for a fixed ventricle size, to date, no freely available models incorporate time and represent the cardiac motion during a complete cardiac cycle. Therefore, we developed four cardiacmechanical left ventricular models with varying ventricle sizes and complexities. Each model focuses on a different aspect of the geometric shape, thus allowing an isolated analysis of the different influences. This paper presents the development of the models and initial results of the impedance analysis. All measured admittances exhibit a high resemblance for all models and a strong, non-linear correlation with the LVV. A comparison between the models shows how the different geometries affect the impedance. The models, thus, provide a useful basis for the development of LVV estimation algorithms.
心血管疾病是全球主要的死亡原因。因此，重症患者需要持续监测心血管指标，如左心室容积（LVV）。尽管对患者进行连续的血流动力学监测是理想的，但由于技术限制，目前的测量技术要么需要医生的手动干预，要么只能提供不准确的结果。心内阻抗测量是一种有前景的连续评估心脏功能的方法。然而，开发和评估这些方法需要一个在整个心动周期中具有心脏运动的左心室模拟模型。虽然存在许多针对固定心室大小的模型，但迄今为止，没有可免费获取的模型能纳入时间并表示完整心动周期中的心脏运动。因此，我们开发了四个具有不同心室大小和复杂度的心脏机械左心室模型。每个模型专注于几何形状的不同方面，从而允许对不同影响进行单独分析。本文介绍了模型的开发以及阻抗分析的初步结果。所有测量的导纳在所有模型中都表现出高度相似性，并且与LVV具有强非线性相关性。模型之间的比较显示了不同几何形状如何影响阻抗。因此，这些模型为LVV估计算法的开发提供了有用的基础。
