外膜通道蛋白TolC与脂多糖特异性噬菌体TLS——原型病毒。
The TolC and Lipopolysaccharide-Specific Bacteriophage TLS-the Archetype Virus.
作者信息
German Gregory J, DeGiulio James V, Ramsey Jolene, Kropinski Andrew M, Misra Rajeev
机构信息
St. Joseph's Health Centre, Unity Health Toronto, Toronto, Canada.
Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada.
出版信息
Phage (New Rochelle). 2024 Sep 16;5(3):173-183. doi: 10.1089/phage.2023.0041. eCollection 2024 Sep.
INTRODUCTION
TLS is a virulent bacteriophage of that utilizes TolC and lipopolysaccharide as its cell surface receptors.
METHODS
The genome was reannotated using the latest online resources and compared to other T1-like phages.
RESULTS
The TLS genome consists of 49,902 base pairs, encoding 86 coding sequences that display considerable sequence similarity with the T1 phage genome. It also contains 18 intergenic 21-base long repeats, each of them upstream of a predicted start codon and in the direction of transcription. Data revealed that DNA packaging occurs through the site-mediated headful mechanism.
CONCLUSIONS
Based on sequence analysis of its genome, TLS belongs to the family and represents the type member of the genus.
引言
TLS是一种烈性噬菌体，它利用TolC和脂多糖作为其细胞表面受体。
方法
利用最新的在线资源对基因组进行重新注释，并与其他T1样噬菌体进行比较。
结果
TLS基因组由49,902个碱基对组成，编码86个编码序列，这些序列与T1噬菌体基因组显示出相当大的序列相似性。它还包含18个基因间21个碱基长的重复序列，每个重复序列都位于预测起始密码子的上游且转录方向相同。数据显示DNA包装通过位点介导的满头部机制发生。
结论
基于其基因组的序列分析，TLS属于该家族，代表该属的典型成员。
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