Zarepour Atefeh, Khosravi Arezoo, Iravani Siavash, Zarrabi Ali
Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India.
Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, Istanbul, Turkiye, 34959.
Adv Healthc Mater. 2024 Dec;13(31):e2402102. doi: 10.1002/adhm.202402102. Epub 2024 Oct 7.
Biohybrid micro/nanorobots hold a great potential for advancing biomedical research. These tiny structures, designed to mimic biological organisms, offer a promising method for targeted drug delivery, tissue engineering, biosensing/imaging, and cancer therapy, among other applications. The integration of biology and robotics opens new possibilities for minimally invasive surgeries and personalized healthcare solutions. The key challenges in the development of biohybrid micro/nanorobots include ensuring biocompatibility, addressing manufacturing scalability, enhancing navigation and localization capabilities, maintaining stability in dynamic biological environments, navigating regulatory hurdles, and successfully translating these innovative technologies into clinical applications. Herein, the recent advancements, challenges, and future perspectives related to the biomedical applications of biohybrid micro/nanorobots are described. Indeed, this review sheds light on the cutting-edge developments in this field, providing researchers with an updated overview of the current potential of biohybrid micro/nanorobots in the realm of biomedical applications, and offering insights into their practical applications. Furthermore, it delves into recent advancements in the field of biohybrid micro/nanorobotics, providing a comprehensive analysis of the current state-of-the-art technologies and their future applications in the biomedical field.
生物杂交微纳机器人在推动生物医学研究方面具有巨大潜力。这些旨在模仿生物有机体的微小结构，为靶向给药、组织工程、生物传感/成像以及癌症治疗等多种应用提供了一种很有前景的方法。生物学与机器人技术的融合为微创手术和个性化医疗解决方案开辟了新的可能性。生物杂交微纳机器人开发中的关键挑战包括确保生物相容性、解决制造可扩展性问题、增强导航和定位能力、在动态生物环境中保持稳定性、跨越监管障碍以及成功将这些创新技术转化为临床应用。本文描述了与生物杂交微纳机器人生物医学应用相关的最新进展、挑战和未来展望。的确，这篇综述揭示了该领域的前沿发展，为研究人员提供了生物杂交微纳机器人在生物医学应用领域当前潜力的最新概述，并对其实际应用提供了见解。此外，它深入探讨了生物杂交微纳机器人领域的最新进展，对当前的先进技术及其在生物医学领域的未来应用进行了全面分析。
