Li Jinhua, Dekanovsky Lukas, Khezri Bahareh, Wu Bing, Zhou Huaijuan, Sofer Zdenek
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic.
Cyborg Bionic Syst. 2022 Feb 10;2022:9824057. doi: 10.34133/2022/9824057. eCollection 2022.
Biohybrid micro- and nanorobots are integrated tiny machines from biological components and artificial components. They can possess the advantages of onboard actuation, sensing, control, and implementation of multiple medical tasks such as targeted drug delivery, single-cell manipulation, and cell microsurgery. This review paper is to give an overview of biohybrid micro- and nanorobots for smart drug delivery applications. First, a wide range of biohybrid micro- and nanorobots comprising different biological components are reviewed in detail. Subsequently, the applications of biohybrid micro- and nanorobots for active drug delivery are introduced to demonstrate how such biohybrid micro- and nanorobots are being exploited in the field of medicine and healthcare. Lastly, key challenges to be overcome are discussed to pave the way for the clinical translation and application of the biohybrid micro- and nanorobots.
生物杂交微纳机器人是由生物组件和人工组件集成的微型机器。它们可以具备板载驱动、传感、控制以及执行多种医疗任务（如靶向给药、单细胞操作和细胞显微手术）的优势。这篇综述文章旨在概述用于智能药物递送应用的生物杂交微纳机器人。首先，详细综述了包括不同生物组件的各种生物杂交微纳机器人。随后，介绍了生物杂交微纳机器人在主动药物递送方面的应用，以展示此类生物杂交微纳机器人如何在医学和医疗保健领域得到应用。最后，讨论了需要克服的关键挑战，为生物杂交微纳机器人的临床转化和应用铺平道路。
