Hawkins P R, Runnegar M T, Jackson A R, Falconer I R
Appl Environ Microbiol. 1985 Nov;50(5):1292-5. doi: 10.1128/aem.50.5.1292-1295.1985.
Cylindrospermopsis raciborskii, a tropical blooming species of cyanobacterium (blue-green alga), was isolated from the domestic water supply reservoir on Palm Island, a continental island off the tropical northeast coast of Australia. This species, not previously known to be toxic, was shown to be severely hepatotoxic for mice. The 50% lethal dose at 24 h after injection was found to be 64 +/- 5 mg of freeze-dried culture per kg of mouse. The principal lesion produced was centrilobular to massive hepatocyte necrosis, but various degrees of injury were also seen in the kidneys, adrenal glands, lungs, and intestine. The possible implication of this finding in relation to an incident of hepatoenteritis in humans living on the island is discussed.
柱孢鱼腥藻是一种热带蓝藻（蓝绿藻），从澳大利亚热带东北海岸大陆岛棕榈岛的家庭供水水库中分离出来。这种以前未知有毒的物种对小鼠具有严重的肝毒性。注射后24小时的半数致死剂量为每千克小鼠64±5毫克冻干培养物。主要病变为小叶中心至大片肝细胞坏死，但在肾脏、肾上腺、肺和肠道中也可见到不同程度的损伤。本文讨论了这一发现与该岛居民发生的一次肝肠炎事件的可能关联。
