• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

髌下脂肪垫部分切除术治疗膝骨关节炎。

Partial excision of infrapatellar fat pad for the treatment of knee osteoarthritis.

机构信息

Orthopedics Department, Guangyuan Central Hospital, Guangyuan, 628000, China.

Orthopedics Department, Jiangshan People's Hospital, Jiangshan, 324199, China.

出版信息

J Orthop Surg Res. 2024 Oct 7;19(1):631. doi: 10.1186/s13018-024-05114-y.

DOI:10.1186/s13018-024-05114-y
PMID:39375685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11457350/
Abstract

AIMS

Knee osteoarthritis (KOA) is a common degenerative joint disease characterized by pain and functional limitations. Current treatments offer symptomatic relief but do not address the underlying pathology. This study explores the role of the infrapatellar fat pad (IFP) in KOA and evaluates the efficacy of its partial arthroscopic excision.

METHODS

A retrospective review was conducted on 37 KOA patients who underwent partial IFP excision. Pain and function were assessed using the WOMAC and VAS scores, while MRI evaluations focused on cartilage health.

RESULTS

Significant postoperative improvements were observed in both pain and functional outcomes, with substantial reductions in WOMAC and VAS scores (P < 0.001). MRI findings demonstrated notable enhancements in cartilage integrity, reflected in significantly improved WORMS scores (P < 0.001).

CONCLUSIONS

Partial excision of the IFP significantly reduces pain and improves function in KOA patients, while also promoting cartilage health. These findings support the IFP's role in KOA pathology and highlight the potential benefits of targeted surgical intervention.

摘要

目的

膝骨关节炎(KOA)是一种常见的退行性关节疾病,其特征为疼痛和功能受限。目前的治疗方法只能缓解症状,而不能解决根本的病理问题。本研究探讨了髌下脂肪垫(IFP)在 KOA 中的作用,并评估了其部分关节镜下切除的疗效。

方法

对 37 例接受部分 IFP 切除的 KOA 患者进行了回顾性研究。采用 WOMAC 和 VAS 评分评估疼痛和功能,MRI 评估侧重于软骨健康。

结果

术后疼痛和功能均有显著改善,WOMAC 和 VAS 评分显著降低(P<0.001)。MRI 结果显示软骨完整性明显改善,WORMS 评分显著提高(P<0.001)。

结论

IFP 的部分切除可显著减轻 KOA 患者的疼痛,改善功能,同时促进软骨健康。这些发现支持 IFP 在 KOA 病理中的作用,并强调了针对该结构进行手术干预的潜在益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/09dff523c524/13018_2024_5114_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/fffd6f1a1d36/13018_2024_5114_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/5f799b4b4587/13018_2024_5114_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/d277be381d51/13018_2024_5114_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/8b7465272ee6/13018_2024_5114_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/64b2ff9891ed/13018_2024_5114_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/1fae67db4741/13018_2024_5114_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/9da638f263e0/13018_2024_5114_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/09dff523c524/13018_2024_5114_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/fffd6f1a1d36/13018_2024_5114_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/5f799b4b4587/13018_2024_5114_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/d277be381d51/13018_2024_5114_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/8b7465272ee6/13018_2024_5114_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/64b2ff9891ed/13018_2024_5114_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/1fae67db4741/13018_2024_5114_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/9da638f263e0/13018_2024_5114_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a6/11457350/09dff523c524/13018_2024_5114_Fig8_HTML.jpg

相似文献

1
Partial excision of infrapatellar fat pad for the treatment of knee osteoarthritis.髌下脂肪垫部分切除术治疗膝骨关节炎。
J Orthop Surg Res. 2024 Oct 7;19(1):631. doi: 10.1186/s13018-024-05114-y.
2
The effect of infrapatellar fat pad excision on complications after minimally invasive TKA: a randomized controlled trial.髌下脂肪垫切除对微创 TKA 后并发症的影响:一项随机对照试验。
Clin Orthop Relat Res. 2014 Feb;472(2):695-701. doi: 10.1007/s11999-013-3321-z. Epub 2013 Oct 18.
3
Quantitative MR evaluation of the infrapatellar fat pad for knee osteoarthritis: using proton density fat fraction and T2* relaxation based on DIXON.基于 DIXON 的质子密度脂肪分数和 T2*弛豫定量 MRI 评估髌下脂肪垫在膝骨关节炎中的应用。
Eur Radiol. 2022 Jul;32(7):4718-4727. doi: 10.1007/s00330-022-08561-5. Epub 2022 Feb 9.
4
The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study.关节镜下应用膝关节髌下脂肪垫细胞浓缩物治疗膝关节软骨损伤的临床疗效:一项前瞻性、随机对照研究。
J Orthop Surg Res. 2021 Jan 28;16(1):87. doi: 10.1186/s13018-021-02224-9.
5
Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature.基于 MRI 的影像组学特征对膝骨关节炎髌下脂肪垫的定量评估
BMC Musculoskelet Disord. 2023 Apr 25;24(1):326. doi: 10.1186/s12891-023-06433-7.
6
Effect of isometric quadriceps exercise on local microcirculation of the infrapatellar fat pad in female patients with knee osteoarthritis.等长股四头肌锻炼对女性膝骨关节炎患者髌下脂肪垫局部微循环的影响。
Osteoarthritis Cartilage. 2024 Oct;32(10):1319-1326. doi: 10.1016/j.joca.2024.05.009. Epub 2024 May 31.
7
Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging Findings of Infrapatellar Fat Pad Signal Abnormalities: Comparison Between Symptomatic and Asymptomatic Knee Osteoarthritis.髌下脂肪垫信号异常的体素内不相干运动弥散加权磁共振成像表现:症状性与无症状性膝骨关节炎的比较。
Acad Radiol. 2023 Jul;30(7):1374-1383. doi: 10.1016/j.acra.2022.11.010. Epub 2023 Jan 4.
8
Relationship between magnetic resonance imaging findings, radiological grading, psychological distress and pain in patients with symptomatic knee osteoarthritis.症状性膝骨关节炎患者的磁共振成像表现、放射学分级、心理困扰与疼痛之间的关系。
Radiol Med. 2017 Dec;122(12):934-943. doi: 10.1007/s11547-017-0799-6. Epub 2017 Aug 22.
9
Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis.正常对照组、中度和终末期骨关节炎患者髌下和髌上脂肪垫的定量MRI分析
Ann Anat. 2019 Jan;221:108-114. doi: 10.1016/j.aanat.2018.09.007. Epub 2018 Oct 4.
10
Evaluation and treatment of disorders of the infrapatellar fat pad.髌下脂肪垫紊乱的评估与治疗。
Sports Med. 2012 Jan 1;42(1):51-67. doi: 10.2165/11595680-000000000-00000.

引用本文的文献

1
A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study.一项关于前交叉韧带重建中一种新型髌下脂肪垫保留技术可减轻术后疼痛并减少软骨损伤的回顾性研究。
J Orthop Surg Res. 2025 Aug 5;20(1):728. doi: 10.1186/s13018-025-06162-8.
2
Observation of the Effects of Infrapatellar Fat Pad Excision on the Inflammatory Progression of Knee Osteoarthritis in Mice.观察髌下脂肪垫切除对小鼠膝骨关节炎炎症进展的影响。
J Inflamm Res. 2025 May 23;18:6653-6672. doi: 10.2147/JIR.S517314. eCollection 2025.

本文引用的文献

1
HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes.HIF1α/TET1 通路介导缺氧诱导的人脂肪细胞脂肪细胞因子启动子低甲基化。
Cells. 2020 Jan 6;9(1):134. doi: 10.3390/cells9010134.
2
Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis.骨关节炎与类风湿关节炎患者髌下脂肪垫和滑液中的脂肪酸特征明显不同。
Arthritis Res Ther. 2019 May 22;21(1):124. doi: 10.1186/s13075-019-1914-y.
3
The infrapatellar fat pad is a dynamic and mobile structure, which deforms during knee motion, and has proximal extensions which wrap around the patella.
髌下脂肪垫是一个动态且可移动的结构,在膝关节运动过程中会发生变形,并且有近端延伸部分环绕髌骨。
Knee Surg Sports Traumatol Arthrosc. 2018 Nov;26(11):3515-3524. doi: 10.1007/s00167-018-4943-1. Epub 2018 Apr 20.
4
Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy.髌下脂肪垫干细胞:从发育生物学到细胞治疗
Stem Cells Int. 2017;2017:6843727. doi: 10.1155/2017/6843727. Epub 2017 Sep 6.
5
Co-culture with infrapatellar fat pad differentially stimulates proteoglycan synthesis and accumulation in cartilage and meniscus tissues.与髌下脂肪垫共培养可不同程度地刺激软骨和半月板组织中蛋白聚糖的合成与积累。
Connect Tissue Res. 2017 Sep;58(5):447-455. doi: 10.1080/03008207.2016.1245728. Epub 2016 Oct 11.
6
Infrapatellar Fat Pad: An Alternative Source of Adipose-Derived Mesenchymal Stem Cells.髌下脂肪垫:脂肪来源间充质干细胞的另一个来源
Arthritis. 2016;2016:4019873. doi: 10.1155/2016/4019873. Epub 2016 Apr 26.
7
The Infrapatellar Adipose Body: A Histotopographic Study.髌下脂肪体:一项组织拓扑学研究。
Cells Tissues Organs. 2016;201(3):220-31. doi: 10.1159/000442876. Epub 2016 Jan 22.
8
Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative.膝关节磁共振成像内侧半月板信号强度的自然史:来自骨关节炎倡议组织的六年数据
Radiology. 2016 Jan;278(1):164-71. doi: 10.1148/radiol.2015142905. Epub 2015 Jul 14.
9
Sphingolipids in human synovial fluid--a lipidomic study.人滑液中的鞘脂——一项脂质组学研究。
PLoS One. 2014 Mar 19;9(3):e91769. doi: 10.1371/journal.pone.0091769. eCollection 2014.
10
An emerging player in knee osteoarthritis: the infrapatellar fat pad.膝骨关节炎中的一个新角色:髌下脂肪垫。
Arthritis Res Ther. 2013;15(6):225. doi: 10.1186/ar4422.