Das Nidhin, Sharma Vidhu, Goyal Amit
Department of Otorhinolaryngology, All India Institute of Medical Sciences,Jodhpur, Jodhpur, India.
Indian J Otolaryngol Head Neck Surg. 2024 Oct;76(5):4949-4957. doi: 10.1007/s12070-024-04801-w. Epub 2024 Jun 17.
Cochlear implant surgery has revolutionized the management of profound hearing loss, with a growing focus on preserving residual hearing, particularly low-frequency hearing. This review synthesizes existing literature on cochlear implantation techniques, surgical principles, and emerging therapies aimed at reducing post-implantation hearing loss. Methodologically, a comprehensive narrative literature review was conducted, encompassing various study designs and participant demographics. The search strategy involved major biomedical databases, focusing on articles in English. Surgical techniques such as "soft surgery" emphasize minimizing mechanical stress on the cochlea, while advancements in pharmacological agents explore the use of corticosteroids, neurotrophins, and growth factors to enhance hearing preservation. Electrode design and insertion strategies are evolving to minimize trauma and optimize hearing outcomes, including consideration of insertion forces and electrode array designs. Evaluating residual hearing loss involves sophisticated techniques like electrocochleography and radiological imaging. The impact of residual hearing on auditory verbal outcomes is variable, with studies indicating positive correlations with language development, particularly in speech production. Emerging strategies in electrode design, surgical techniques, and drug delivery hold promise for improving outcomes in cochlear implantation. However, challenges such as the lack of standardized guidelines and the need for further clinical trials remain. Future directions include the exploration of nanotechnologies, gene therapies, and stem cells for constructing bionic ears, although ethical and technical hurdles persist. This review underscores the ongoing efforts to enhance cochlear implant functionality and the need for continued research to optimize outcomes for patients with hearing loss.
人工耳蜗植入手术彻底改变了重度听力损失的治疗方式,越来越注重保留残余听力,尤其是低频听力。本综述综合了关于人工耳蜗植入技术、手术原则以及旨在减少植入后听力损失的新兴疗法的现有文献。在方法上,进行了全面的叙述性文献综述,涵盖了各种研究设计和参与者人口统计学特征。检索策略涉及主要的生物医学数据库,重点关注英文文章。诸如“软手术”之类的手术技术强调将对耳蜗的机械应力降至最低,而药物制剂的进展则探索使用皮质类固醇、神经营养因子和生长因子来增强听力保留。电极设计和插入策略正在不断发展,以尽量减少创伤并优化听力结果,包括考虑插入力和电极阵列设计。评估残余听力损失涉及电耳蜗图和放射成像等复杂技术。残余听力对听觉言语结果的影响各不相同,研究表明其与语言发展呈正相关,尤其是在言语产生方面。电极设计、手术技术和药物递送方面的新兴策略有望改善人工耳蜗植入的效果。然而,诸如缺乏标准化指南以及需要进一步进行临床试验等挑战仍然存在。未来的方向包括探索用于构建仿生耳的纳米技术、基因疗法和干细胞,尽管伦理和技术障碍依然存在。本综述强调了为提高人工耳蜗功能而持续做出的努力,以及为优化听力损失患者的治疗效果而持续开展研究的必要性。